CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine

We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves...

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Detalles Bibliográficos
Autores principales: Ale-Agha, Niloofar, Goy, Christine, Jakobs, Philipp, Spyridopoulos, Ioakim, Gonnissen, Stefanie, Dyballa-Rukes, Nadine, Aufenvenne, Karin, von Ameln, Florian, Zurek, Mark, Spannbrucker, Tim, Eckermann, Olaf, Jakob, Sascha, Gorressen, Simone, Abrams, Marcel, Grandoch, Maria, Fischer, Jens W., Köhrer, Karl, Deenen, René, Unfried, Klaus, Altschmied, Joachim, Haendeler, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013014/
https://www.ncbi.nlm.nih.gov/pubmed/29927970
http://dx.doi.org/10.1371/journal.pbio.2004408

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