Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation

Nuclear factor κB (NF-κB) is a transcription factor important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, and senescence. Dysregulation of NF-κB and its upstream regulator IκB kinase (IKK) contributes to the pathogenesis of multiple inflammatory and degenerative d...

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Detalles Bibliográficos
Autores principales: Zhao, Jing, Zhang, Lei, Mu, Xiaodong, Doebelin, Christelle, Nguyen, William, Wallace, Callen, Reay, Daniel P., McGowan, Sara J., Corbo, Lana, Clemens, Paula R., Wilson, Gabriela Mustata, Watkins, Simon C., Solt, Laura A., Cameron, Michael D., Huard, Johnny, Niedernhofer, Laura J., Kamenecka, Theodore M., Robbins, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013238/
https://www.ncbi.nlm.nih.gov/pubmed/29889904
http://dx.doi.org/10.1371/journal.pbio.2004663

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