Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient

We sequenced the genome of Raoultella ornithinolytica strain Marseille-P1025 that caused a rare case of prosthetic joint infection in a 67-year-old immunocompetent male. The 6.7-Mb genome exhibited a genomic island (RoGI) that was unique among R. ornithinolytica strains. RoGI was likely acquired by...

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Autores principales: Beye, Mamadou, Hasni, Issam, Seng, Piseth, Michelle, Caroline, La Scola, Bernard, Raoult, Didier, Fournier, Pierre-Edouard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013458/
https://www.ncbi.nlm.nih.gov/pubmed/29930334
http://dx.doi.org/10.1038/s41598-018-27833-z
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author Beye, Mamadou
Hasni, Issam
Seng, Piseth
Michelle, Caroline
La Scola, Bernard
Raoult, Didier
Fournier, Pierre-Edouard
author_facet Beye, Mamadou
Hasni, Issam
Seng, Piseth
Michelle, Caroline
La Scola, Bernard
Raoult, Didier
Fournier, Pierre-Edouard
author_sort Beye, Mamadou
collection PubMed
description We sequenced the genome of Raoultella ornithinolytica strain Marseille-P1025 that caused a rare case of prosthetic joint infection in a 67-year-old immunocompetent male. The 6.7-Mb genome exhibited a genomic island (RoGI) that was unique among R. ornithinolytica strains. RoGI was likely acquired by lateral gene transfer from a member of the Pectobacterium genus and coded for a type IVa secretion system found in other pathogenic bacteria and that may have conferred strain Marseille-P1025 an increased virulence. Strain Marseille-P1025 was also able to infect, multiply within, and kill Acanthamoaeba castellanii amoebae.
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spelling pubmed-60134582018-06-27 Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient Beye, Mamadou Hasni, Issam Seng, Piseth Michelle, Caroline La Scola, Bernard Raoult, Didier Fournier, Pierre-Edouard Sci Rep Article We sequenced the genome of Raoultella ornithinolytica strain Marseille-P1025 that caused a rare case of prosthetic joint infection in a 67-year-old immunocompetent male. The 6.7-Mb genome exhibited a genomic island (RoGI) that was unique among R. ornithinolytica strains. RoGI was likely acquired by lateral gene transfer from a member of the Pectobacterium genus and coded for a type IVa secretion system found in other pathogenic bacteria and that may have conferred strain Marseille-P1025 an increased virulence. Strain Marseille-P1025 was also able to infect, multiply within, and kill Acanthamoaeba castellanii amoebae. Nature Publishing Group UK 2018-06-21 /pmc/articles/PMC6013458/ /pubmed/29930334 http://dx.doi.org/10.1038/s41598-018-27833-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Beye, Mamadou
Hasni, Issam
Seng, Piseth
Michelle, Caroline
La Scola, Bernard
Raoult, Didier
Fournier, Pierre-Edouard
Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient
title Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient
title_full Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient
title_fullStr Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient
title_full_unstemmed Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient
title_short Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient
title_sort genomic analysis of a raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013458/
https://www.ncbi.nlm.nih.gov/pubmed/29930334
http://dx.doi.org/10.1038/s41598-018-27833-z
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