The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes

PURPOSE OF REVIEW: The objective of this review is to critically assess the contributing role of the gut microbiota in human obesity and type 2 diabetes (T2D). RECENT FINDINGS: Experiments in animal and human studies have produced growing evidence for the causality of the gut microbiome in developin...

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Autores principales: Aydin, Ömrüm, Nieuwdorp, Max, Gerdes, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Genetics (AP Morris, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013535/
https://www.ncbi.nlm.nih.gov/pubmed/29931613
http://dx.doi.org/10.1007/s11892-018-1020-6
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author Aydin, Ömrüm
Nieuwdorp, Max
Gerdes, Victor
author_facet Aydin, Ömrüm
Nieuwdorp, Max
Gerdes, Victor
author_sort Aydin, Ömrüm
collection PubMed
description PURPOSE OF REVIEW: The objective of this review is to critically assess the contributing role of the gut microbiota in human obesity and type 2 diabetes (T2D). RECENT FINDINGS: Experiments in animal and human studies have produced growing evidence for the causality of the gut microbiome in developing obesity and T2D. The introduction of high-throughput sequencing technologies has provided novel insight into the interpersonal differences in microbiome composition and function. SUMMARY: The intestinal microbiota is known to be associated with metabolic syndrome and related comorbidities. Associated diseases including obesity, T2D, and fatty liver disease (NAFLD/NASH) all seem to be linked to altered microbial composition; however, causality has not been proven yet. Elucidating the potential causal and personalized role of the human gut microbiota in obesity and T2D is highly prioritized.
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spelling pubmed-60135352018-06-25 The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes Aydin, Ömrüm Nieuwdorp, Max Gerdes, Victor Curr Diab Rep Genetics (AP Morris, Section Editor) PURPOSE OF REVIEW: The objective of this review is to critically assess the contributing role of the gut microbiota in human obesity and type 2 diabetes (T2D). RECENT FINDINGS: Experiments in animal and human studies have produced growing evidence for the causality of the gut microbiome in developing obesity and T2D. The introduction of high-throughput sequencing technologies has provided novel insight into the interpersonal differences in microbiome composition and function. SUMMARY: The intestinal microbiota is known to be associated with metabolic syndrome and related comorbidities. Associated diseases including obesity, T2D, and fatty liver disease (NAFLD/NASH) all seem to be linked to altered microbial composition; however, causality has not been proven yet. Elucidating the potential causal and personalized role of the human gut microbiota in obesity and T2D is highly prioritized. Springer US 2018-06-21 2018 /pmc/articles/PMC6013535/ /pubmed/29931613 http://dx.doi.org/10.1007/s11892-018-1020-6 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Genetics (AP Morris, Section Editor)
Aydin, Ömrüm
Nieuwdorp, Max
Gerdes, Victor
The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
title The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
title_full The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
title_fullStr The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
title_full_unstemmed The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
title_short The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
title_sort gut microbiome as a target for the treatment of type 2 diabetes
topic Genetics (AP Morris, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013535/
https://www.ncbi.nlm.nih.gov/pubmed/29931613
http://dx.doi.org/10.1007/s11892-018-1020-6
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