Nanoparticle transport pathways into tumors

Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenue...

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Detalles Bibliográficos
Autores principales: Moghimi, S. M., Simberg, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013540/
https://www.ncbi.nlm.nih.gov/pubmed/29950922
http://dx.doi.org/10.1007/s11051-018-4273-8
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author Moghimi, S. M.
Simberg, D.
author_facet Moghimi, S. M.
Simberg, D.
author_sort Moghimi, S. M.
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description Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenues for re-evaluating these pathways. Understanding of integrative mechanisms controlling nanoparticle extravasation into tumors is important for improving engineering and performance of anti-cancer nanopharmaceuticals.
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spelling pubmed-60135402018-06-25 Nanoparticle transport pathways into tumors Moghimi, S. M. Simberg, D. J Nanopart Res Perspectives Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenues for re-evaluating these pathways. Understanding of integrative mechanisms controlling nanoparticle extravasation into tumors is important for improving engineering and performance of anti-cancer nanopharmaceuticals. Springer Netherlands 2018-06-21 2018 /pmc/articles/PMC6013540/ /pubmed/29950922 http://dx.doi.org/10.1007/s11051-018-4273-8 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Perspectives
Moghimi, S. M.
Simberg, D.
Nanoparticle transport pathways into tumors
title Nanoparticle transport pathways into tumors
title_full Nanoparticle transport pathways into tumors
title_fullStr Nanoparticle transport pathways into tumors
title_full_unstemmed Nanoparticle transport pathways into tumors
title_short Nanoparticle transport pathways into tumors
title_sort nanoparticle transport pathways into tumors
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013540/
https://www.ncbi.nlm.nih.gov/pubmed/29950922
http://dx.doi.org/10.1007/s11051-018-4273-8
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