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The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis

Research into the pathophysiology of psoriasis has shed light onto many fascinating immunological interactions and underlying genetic constellations. Most prominent among these is the crosstalk between components of the innate and the adaptive immune system and the crucial role of interleukins (IL)-...

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Autores principales: Schön, Michael P., Erpenbeck, Luise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013559/
https://www.ncbi.nlm.nih.gov/pubmed/29963046
http://dx.doi.org/10.3389/fimmu.2018.01323
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author Schön, Michael P.
Erpenbeck, Luise
author_facet Schön, Michael P.
Erpenbeck, Luise
author_sort Schön, Michael P.
collection PubMed
description Research into the pathophysiology of psoriasis has shed light onto many fascinating immunological interactions and underlying genetic constellations. Most prominent among these is the crosstalk between components of the innate and the adaptive immune system and the crucial role of interleukins (IL)-23 and -17 within this network. While it is clear that IL-23 drives and maintains the differentiation of Th17 lymphocytes, many aspects of the regulation of IL-23 and IL-17 are not quite as straightforward and have been unraveled only recently. For example, we know now that Th17 cells are not the only source of IL-17 but that cells of the innate immune system also produce considerable amounts of this central effector cytokine. In addition, there is IL-23-independent production of IL-17. Besides other innate immune cells, neutrophilic granulocytes prominently contribute to IL-17-related immune regulations in psoriasis, and it appears that they employ several mechanisms including the formation of neutrophil extracellular traps. Here, we strive to put the central role of the IL-23/IL-17 axis into perspective within the crosstalk between components of the innate and the adaptive immune system. Our aim is to better understand the complex immune regulation in psoriasis, a disorder that has become a model disease for chronic inflammation.
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spelling pubmed-60135592018-06-29 The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis Schön, Michael P. Erpenbeck, Luise Front Immunol Immunology Research into the pathophysiology of psoriasis has shed light onto many fascinating immunological interactions and underlying genetic constellations. Most prominent among these is the crosstalk between components of the innate and the adaptive immune system and the crucial role of interleukins (IL)-23 and -17 within this network. While it is clear that IL-23 drives and maintains the differentiation of Th17 lymphocytes, many aspects of the regulation of IL-23 and IL-17 are not quite as straightforward and have been unraveled only recently. For example, we know now that Th17 cells are not the only source of IL-17 but that cells of the innate immune system also produce considerable amounts of this central effector cytokine. In addition, there is IL-23-independent production of IL-17. Besides other innate immune cells, neutrophilic granulocytes prominently contribute to IL-17-related immune regulations in psoriasis, and it appears that they employ several mechanisms including the formation of neutrophil extracellular traps. Here, we strive to put the central role of the IL-23/IL-17 axis into perspective within the crosstalk between components of the innate and the adaptive immune system. Our aim is to better understand the complex immune regulation in psoriasis, a disorder that has become a model disease for chronic inflammation. Frontiers Media S.A. 2018-06-15 /pmc/articles/PMC6013559/ /pubmed/29963046 http://dx.doi.org/10.3389/fimmu.2018.01323 Text en Copyright © 2018 Schön and Erpenbeck. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Schön, Michael P.
Erpenbeck, Luise
The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis
title The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis
title_full The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis
title_fullStr The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis
title_full_unstemmed The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis
title_short The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis
title_sort interleukin-23/interleukin-17 axis links adaptive and innate immunity in psoriasis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013559/
https://www.ncbi.nlm.nih.gov/pubmed/29963046
http://dx.doi.org/10.3389/fimmu.2018.01323
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