T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice

CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice. However, in humans, transplantation with CoB has been hampered by CoB-resistant rejection (CoBRR). CoBRR has been attributed in part to pathogen-d...

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Detalles Bibliográficos
Autores principales: Espinosa, Jaclyn R., Mou, Danny, Adams, Bartley W., DiBernardo, Louis R., MacDonald, Andrea L., McRae, MacKenzie, Miller, Allison N., Song, Mingqing, Stempora, Linda L., Wang, Jun, Iwakoshi, Neal N., Kirk, Allan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013589/
https://www.ncbi.nlm.nih.gov/pubmed/29963060
http://dx.doi.org/10.3389/fimmu.2018.01371

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