Shooting the messenger: RNA-targetting CRISPR-Cas systems

Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed...

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Detalles Bibliográficos
Autores principales: Zhu, Yifan, Klompe, Sanne E., Vlot, Marnix, van der Oost, John, Staals, Raymond H.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013697/
https://www.ncbi.nlm.nih.gov/pubmed/29748239
http://dx.doi.org/10.1042/BSR20170788
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author Zhu, Yifan
Klompe, Sanne E.
Vlot, Marnix
van der Oost, John
Staals, Raymond H.J.
author_facet Zhu, Yifan
Klompe, Sanne E.
Vlot, Marnix
van der Oost, John
Staals, Raymond H.J.
author_sort Zhu, Yifan
collection PubMed
description Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.
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spelling pubmed-60136972018-07-06 Shooting the messenger: RNA-targetting CRISPR-Cas systems Zhu, Yifan Klompe, Sanne E. Vlot, Marnix van der Oost, John Staals, Raymond H.J. Biosci Rep Review Articles Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications. Portland Press Ltd. 2018-06-21 /pmc/articles/PMC6013697/ /pubmed/29748239 http://dx.doi.org/10.1042/BSR20170788 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Zhu, Yifan
Klompe, Sanne E.
Vlot, Marnix
van der Oost, John
Staals, Raymond H.J.
Shooting the messenger: RNA-targetting CRISPR-Cas systems
title Shooting the messenger: RNA-targetting CRISPR-Cas systems
title_full Shooting the messenger: RNA-targetting CRISPR-Cas systems
title_fullStr Shooting the messenger: RNA-targetting CRISPR-Cas systems
title_full_unstemmed Shooting the messenger: RNA-targetting CRISPR-Cas systems
title_short Shooting the messenger: RNA-targetting CRISPR-Cas systems
title_sort shooting the messenger: rna-targetting crispr-cas systems
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013697/
https://www.ncbi.nlm.nih.gov/pubmed/29748239
http://dx.doi.org/10.1042/BSR20170788
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