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OA-GL21, a novel bioactive peptide from Odorrana andersonii, accelerated the healing of skin wounds
Nowadays, the number of chronic trauma cases caused by a variety of factors such as the world’s population-ageing and chronic diseases is increasing steadily, and thus effective treatment for chronic wounds has become a severe clinical challenge, which also burdens the patient both physically and fi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013704/ https://www.ncbi.nlm.nih.gov/pubmed/29752337 http://dx.doi.org/10.1042/BSR20180215 |
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author | Bian, Wenxin Meng, Buliang Li, Xiaojie Wang, Siyuan Cao, Xiaoqing Liu, Naixin Yang, Meifeng Tang, Jing Wang, Ying Yang, Xinwang |
author_facet | Bian, Wenxin Meng, Buliang Li, Xiaojie Wang, Siyuan Cao, Xiaoqing Liu, Naixin Yang, Meifeng Tang, Jing Wang, Ying Yang, Xinwang |
author_sort | Bian, Wenxin |
collection | PubMed |
description | Nowadays, the number of chronic trauma cases caused by a variety of factors such as the world’s population-ageing and chronic diseases is increasing steadily, and thus effective treatment for chronic wounds has become a severe clinical challenge, which also burdens the patient both physically and financially. Therefore, it is urgent to develop new drugs to accelerate the healing of wounds. Bioactive peptides, which are relatively low cost, easy to produce, store and transport, have become an excellent choice. In this research, we identified a novel peptide OA-GL21, with an amino acid sequence of ‘GLLSGHYGRVVSTQSGHYGRG’, from the skin secretions of Odorrana andersonii. Our results showed that OA-GL21 exerted the ability to promote wound healing of human keratinocytes (HaCaT) and human fibroblasts in a dose- and time-denpendent manner. However, OA-GL21 had no significant effect on the proliferation of these two cells. Significantly, OA-GL21 showed obvious ability to promote wound healing in the full-thickness skin wound model in dose- and scar-free manners. Further studies showed that OA-GL21 had no direct antibacterial, hemolytic, and acute toxic activity; it had weak antioxidant activities but high stability. In conclusion, this research proved the promoting effects of OA-GL21 on cellular and animal wounds, and thus provided a new peptide template for the development of wound-repairing drugs. |
format | Online Article Text |
id | pubmed-6013704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60137042018-07-06 OA-GL21, a novel bioactive peptide from Odorrana andersonii, accelerated the healing of skin wounds Bian, Wenxin Meng, Buliang Li, Xiaojie Wang, Siyuan Cao, Xiaoqing Liu, Naixin Yang, Meifeng Tang, Jing Wang, Ying Yang, Xinwang Biosci Rep Research Articles Nowadays, the number of chronic trauma cases caused by a variety of factors such as the world’s population-ageing and chronic diseases is increasing steadily, and thus effective treatment for chronic wounds has become a severe clinical challenge, which also burdens the patient both physically and financially. Therefore, it is urgent to develop new drugs to accelerate the healing of wounds. Bioactive peptides, which are relatively low cost, easy to produce, store and transport, have become an excellent choice. In this research, we identified a novel peptide OA-GL21, with an amino acid sequence of ‘GLLSGHYGRVVSTQSGHYGRG’, from the skin secretions of Odorrana andersonii. Our results showed that OA-GL21 exerted the ability to promote wound healing of human keratinocytes (HaCaT) and human fibroblasts in a dose- and time-denpendent manner. However, OA-GL21 had no significant effect on the proliferation of these two cells. Significantly, OA-GL21 showed obvious ability to promote wound healing in the full-thickness skin wound model in dose- and scar-free manners. Further studies showed that OA-GL21 had no direct antibacterial, hemolytic, and acute toxic activity; it had weak antioxidant activities but high stability. In conclusion, this research proved the promoting effects of OA-GL21 on cellular and animal wounds, and thus provided a new peptide template for the development of wound-repairing drugs. Portland Press Ltd. 2018-06-21 /pmc/articles/PMC6013704/ /pubmed/29752337 http://dx.doi.org/10.1042/BSR20180215 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Bian, Wenxin Meng, Buliang Li, Xiaojie Wang, Siyuan Cao, Xiaoqing Liu, Naixin Yang, Meifeng Tang, Jing Wang, Ying Yang, Xinwang OA-GL21, a novel bioactive peptide from Odorrana andersonii, accelerated the healing of skin wounds |
title | OA-GL21, a novel bioactive peptide from Odorrana andersonii, accelerated the healing of skin wounds |
title_full | OA-GL21, a novel bioactive peptide from Odorrana andersonii, accelerated the healing of skin wounds |
title_fullStr | OA-GL21, a novel bioactive peptide from Odorrana andersonii, accelerated the healing of skin wounds |
title_full_unstemmed | OA-GL21, a novel bioactive peptide from Odorrana andersonii, accelerated the healing of skin wounds |
title_short | OA-GL21, a novel bioactive peptide from Odorrana andersonii, accelerated the healing of skin wounds |
title_sort | oa-gl21, a novel bioactive peptide from odorrana andersonii, accelerated the healing of skin wounds |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013704/ https://www.ncbi.nlm.nih.gov/pubmed/29752337 http://dx.doi.org/10.1042/BSR20180215 |
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