Cargando…
The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility
Nucleotide excision repair (NER), the core mechanism of DNA repair pathway, was commonly used to maintain genomic stability and prevent tumorigenesis. Previous investigations have demonstrated that single nucleotide polymorphisms (SNPs) of NER pathway genes were associated with various types of canc...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013708/ https://www.ncbi.nlm.nih.gov/pubmed/29669843 http://dx.doi.org/10.1042/BSR20180114 |
_version_ | 1783334067957137408 |
---|---|
author | Zhao, Zhiguang Zhang, Anqi Zhao, Yuan Xiang, Junmiao Yu, Danyang Liang, Zongwen Xu, Chaoyi Zhang, Qiong Li, Jianmin Duan, Ping |
author_facet | Zhao, Zhiguang Zhang, Anqi Zhao, Yuan Xiang, Junmiao Yu, Danyang Liang, Zongwen Xu, Chaoyi Zhang, Qiong Li, Jianmin Duan, Ping |
author_sort | Zhao, Zhiguang |
collection | PubMed |
description | Nucleotide excision repair (NER), the core mechanism of DNA repair pathway, was commonly used to maintain genomic stability and prevent tumorigenesis. Previous investigations have demonstrated that single nucleotide polymorphisms (SNPs) of NER pathway genes were associated with various types of cancer. However, there was no research elucidating the genetic association of entire NER pathway with ovarian cancer susceptibility. Therefore, we conducted genotyping for 17 SNPs of six NER core genes (XPA, XPC, XPG, ERCC1, ERCC2, and ERCC4) in 89 ovarian cancer cases and 356 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to describe the strength of association. The result showed that both ERCC1 rs11615 and XPC rs2228000 were significantly associated with reduced risk of ovarian cancer under dominant genetic model (adjusted OR = 0.35, 95% CI = 0.20–0.61, P=0.0002 and adjusted OR = 0.49, 95% CI = 0.30–0.81, P=0.005 respectively). In addition, XPC rs2228001 and ERCC2 rs238406 had statistically significant association with the increased risk of ovarian cancer under dominant genetic model (adjusted OR = 1.72, 95% CI = 1.02–2.92, P=0.043 and adjusted OR = 2.07, 95% CI = 1.07–4.01, P=0.032 respectively). ERCC1 rs3212986 were related with the increased risk of ovarian cancer under recessive model (adjusted OR = 2.40, 95% CI = 1.30–4.44, P=0.005). In conclusion, our results indicated that ERCC1, XPC and ERCC2 might influence ovarian cancer susceptibility. Further research with large sample size is warranted to validate the reliability and accuracy of our results. |
format | Online Article Text |
id | pubmed-6013708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60137082018-07-06 The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility Zhao, Zhiguang Zhang, Anqi Zhao, Yuan Xiang, Junmiao Yu, Danyang Liang, Zongwen Xu, Chaoyi Zhang, Qiong Li, Jianmin Duan, Ping Biosci Rep Research Articles Nucleotide excision repair (NER), the core mechanism of DNA repair pathway, was commonly used to maintain genomic stability and prevent tumorigenesis. Previous investigations have demonstrated that single nucleotide polymorphisms (SNPs) of NER pathway genes were associated with various types of cancer. However, there was no research elucidating the genetic association of entire NER pathway with ovarian cancer susceptibility. Therefore, we conducted genotyping for 17 SNPs of six NER core genes (XPA, XPC, XPG, ERCC1, ERCC2, and ERCC4) in 89 ovarian cancer cases and 356 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to describe the strength of association. The result showed that both ERCC1 rs11615 and XPC rs2228000 were significantly associated with reduced risk of ovarian cancer under dominant genetic model (adjusted OR = 0.35, 95% CI = 0.20–0.61, P=0.0002 and adjusted OR = 0.49, 95% CI = 0.30–0.81, P=0.005 respectively). In addition, XPC rs2228001 and ERCC2 rs238406 had statistically significant association with the increased risk of ovarian cancer under dominant genetic model (adjusted OR = 1.72, 95% CI = 1.02–2.92, P=0.043 and adjusted OR = 2.07, 95% CI = 1.07–4.01, P=0.032 respectively). ERCC1 rs3212986 were related with the increased risk of ovarian cancer under recessive model (adjusted OR = 2.40, 95% CI = 1.30–4.44, P=0.005). In conclusion, our results indicated that ERCC1, XPC and ERCC2 might influence ovarian cancer susceptibility. Further research with large sample size is warranted to validate the reliability and accuracy of our results. Portland Press Ltd. 2018-06-21 /pmc/articles/PMC6013708/ /pubmed/29669843 http://dx.doi.org/10.1042/BSR20180114 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Zhao, Zhiguang Zhang, Anqi Zhao, Yuan Xiang, Junmiao Yu, Danyang Liang, Zongwen Xu, Chaoyi Zhang, Qiong Li, Jianmin Duan, Ping The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility |
title | The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility |
title_full | The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility |
title_fullStr | The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility |
title_full_unstemmed | The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility |
title_short | The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility |
title_sort | association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013708/ https://www.ncbi.nlm.nih.gov/pubmed/29669843 http://dx.doi.org/10.1042/BSR20180114 |
work_keys_str_mv | AT zhaozhiguang theassociationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT zhanganqi theassociationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT zhaoyuan theassociationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT xiangjunmiao theassociationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT yudanyang theassociationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT liangzongwen theassociationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT xuchaoyi theassociationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT zhangqiong theassociationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT lijianmin theassociationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT duanping theassociationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT zhaozhiguang associationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT zhanganqi associationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT zhaoyuan associationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT xiangjunmiao associationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT yudanyang associationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT liangzongwen associationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT xuchaoyi associationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT zhangqiong associationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT lijianmin associationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility AT duanping associationofpolymorphismsinnucleotideexcisionrepairgeneswithovariancancersusceptibility |