A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination

Upon ligand engagement, the single-pass transmembrane receptor tyrosine kinases (RTKs) dimerize to transmit qualitatively and quantitatively different intracellular signals that alter the transcriptional landscape and thereby determine the cellular response. The molecular mechanisms underlying these...

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Detalles Bibliográficos
Autores principales: Zinkle, Allen, Mohammadi, Moosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013765/
https://www.ncbi.nlm.nih.gov/pubmed/29983915
http://dx.doi.org/10.12688/f1000research.14143.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013765/
https://www.ncbi.nlm.nih.gov/pubmed/29983915
http://dx.doi.org/10.12688/f1000research.14143.1

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