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A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination
Upon ligand engagement, the single-pass transmembrane receptor tyrosine kinases (RTKs) dimerize to transmit qualitatively and quantitatively different intracellular signals that alter the transcriptional landscape and thereby determine the cellular response. The molecular mechanisms underlying these...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
F1000 Research Limited
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013765/ https://www.ncbi.nlm.nih.gov/pubmed/29983915 http://dx.doi.org/10.12688/f1000research.14143.1 |