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Inhibition of the key enzyme of sialic acid biosynthesis by C6-Se modified N-acetylmannosamine analogs

Synthetically accessible C6-analogs of N-acetylmannosamine (ManNAc) were tested as potential inhibitors of the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE/MNK), the key enzyme of sialic acid biosynthesis. Enzymatic experiments revealed that the modification intro...

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Detalles Bibliográficos
Autores principales:	Nieto-Garcia, Olaia, Wratil, Paul R., Nguyen, Long D., Böhrsch, Verena, Hinderlich, Stephan, Reutter, Werner, Hackenberger, Christian P. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013775/ https://www.ncbi.nlm.nih.gov/pubmed/30155038 http://dx.doi.org/10.1039/c5sc04082e

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