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Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

Stem cell (SC) dynamics within the human colorectal crypt SC niche remain poorly understood, with previous studies proposing divergent hypotheses on the predominant mode of SC self-renewal and the rate of SC replacement. Here we use age-related mitochondrial oxidative phosphorylation (OXPHOS) defect...

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Detalles Bibliográficos
Autores principales:	Stamp, Craig, Zupanic, Anze, Sachdeva, Ashwin, Stoll, Elizabeth A., Shanley, Daryl P., Mathers, John C., Kirkwood, Thomas B.L., Heer, Rakesh, Simons, Benjamin D., Turnbull, Doug M., Greaves, Laura C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013780/ https://www.ncbi.nlm.nih.gov/pubmed/29748033 http://dx.doi.org/10.1016/j.ebiom.2018.04.017

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