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Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
Methods to incorporate atmospheric CO(2) into organic molecules are on demand. Here we present two Pd-catalyzed multicomponent reactions that provide functionalized oxazolidinones from propargylamines, aryl halides and CO(2) as starting materials. These transformations, devoid of high CO(2) pressure...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Royal Society of Chemistry
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013789/ https://www.ncbi.nlm.nih.gov/pubmed/30155036 http://dx.doi.org/10.1039/c6sc00419a |
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author | García-Domínguez, Patricia Fehr, Lorenz Rusconi, Giulia Nevado, Cristina |
author_facet | García-Domínguez, Patricia Fehr, Lorenz Rusconi, Giulia Nevado, Cristina |
author_sort | García-Domínguez, Patricia |
collection | PubMed |
description | Methods to incorporate atmospheric CO(2) into organic molecules are on demand. Here we present two Pd-catalyzed multicomponent reactions that provide functionalized oxazolidinones from propargylamines, aryl halides and CO(2) as starting materials. These transformations, devoid of high CO(2) pressures, represent a streamlined stereocontrolled synthesis of previously inaccessible versions of these useful heterocycles in an atom-economic manner, as up to four new single bonds are formed in a single synthetic operation. |
format | Online Article Text |
id | pubmed-6013789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-60137892018-08-28 Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones García-Domínguez, Patricia Fehr, Lorenz Rusconi, Giulia Nevado, Cristina Chem Sci Chemistry Methods to incorporate atmospheric CO(2) into organic molecules are on demand. Here we present two Pd-catalyzed multicomponent reactions that provide functionalized oxazolidinones from propargylamines, aryl halides and CO(2) as starting materials. These transformations, devoid of high CO(2) pressures, represent a streamlined stereocontrolled synthesis of previously inaccessible versions of these useful heterocycles in an atom-economic manner, as up to four new single bonds are formed in a single synthetic operation. Royal Society of Chemistry 2016-06-01 2016-03-10 /pmc/articles/PMC6013789/ /pubmed/30155036 http://dx.doi.org/10.1039/c6sc00419a Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
spellingShingle | Chemistry García-Domínguez, Patricia Fehr, Lorenz Rusconi, Giulia Nevado, Cristina Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones |
title | Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
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title_full | Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
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title_fullStr | Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
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title_full_unstemmed | Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
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title_short | Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
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title_sort | palladium-catalyzed incorporation of atmospheric co(2): efficient synthesis of functionalized oxazolidinones |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013789/ https://www.ncbi.nlm.nih.gov/pubmed/30155036 http://dx.doi.org/10.1039/c6sc00419a |
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