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Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones

Methods to incorporate atmospheric CO(2) into organic molecules are on demand. Here we present two Pd-catalyzed multicomponent reactions that provide functionalized oxazolidinones from propargylamines, aryl halides and CO(2) as starting materials. These transformations, devoid of high CO(2) pressure...

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Autores principales: García-Domínguez, Patricia, Fehr, Lorenz, Rusconi, Giulia, Nevado, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013789/
https://www.ncbi.nlm.nih.gov/pubmed/30155036
http://dx.doi.org/10.1039/c6sc00419a
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author García-Domínguez, Patricia
Fehr, Lorenz
Rusconi, Giulia
Nevado, Cristina
author_facet García-Domínguez, Patricia
Fehr, Lorenz
Rusconi, Giulia
Nevado, Cristina
author_sort García-Domínguez, Patricia
collection PubMed
description Methods to incorporate atmospheric CO(2) into organic molecules are on demand. Here we present two Pd-catalyzed multicomponent reactions that provide functionalized oxazolidinones from propargylamines, aryl halides and CO(2) as starting materials. These transformations, devoid of high CO(2) pressures, represent a streamlined stereocontrolled synthesis of previously inaccessible versions of these useful heterocycles in an atom-economic manner, as up to four new single bonds are formed in a single synthetic operation.
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spelling pubmed-60137892018-08-28 Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones García-Domínguez, Patricia Fehr, Lorenz Rusconi, Giulia Nevado, Cristina Chem Sci Chemistry Methods to incorporate atmospheric CO(2) into organic molecules are on demand. Here we present two Pd-catalyzed multicomponent reactions that provide functionalized oxazolidinones from propargylamines, aryl halides and CO(2) as starting materials. These transformations, devoid of high CO(2) pressures, represent a streamlined stereocontrolled synthesis of previously inaccessible versions of these useful heterocycles in an atom-economic manner, as up to four new single bonds are formed in a single synthetic operation. Royal Society of Chemistry 2016-06-01 2016-03-10 /pmc/articles/PMC6013789/ /pubmed/30155036 http://dx.doi.org/10.1039/c6sc00419a Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
García-Domínguez, Patricia
Fehr, Lorenz
Rusconi, Giulia
Nevado, Cristina
Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
title Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
title_full Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
title_fullStr Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
title_full_unstemmed Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
title_short Palladium-catalyzed incorporation of atmospheric CO(2): efficient synthesis of functionalized oxazolidinones
title_sort palladium-catalyzed incorporation of atmospheric co(2): efficient synthesis of functionalized oxazolidinones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013789/
https://www.ncbi.nlm.nih.gov/pubmed/30155036
http://dx.doi.org/10.1039/c6sc00419a
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