Cargando…

Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment

Due to the differences in the cavity size of the hosts and the charge and length of the guests, a cationic water-soluble pillar[6]arene (WP6) selectively complexes with ATP to form a stable 1 : 1 inclusion complex WP6⊃ATP. This host–guest complexation was utilized to efficiently inhibit the hydrolys...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Guocan, Zhou, Jiong, Shen, Jie, Tang, Guping, Huang, Feihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013913/
https://www.ncbi.nlm.nih.gov/pubmed/30155051
http://dx.doi.org/10.1039/c6sc00531d
_version_ 1783334120294711296
author Yu, Guocan
Zhou, Jiong
Shen, Jie
Tang, Guping
Huang, Feihe
author_facet Yu, Guocan
Zhou, Jiong
Shen, Jie
Tang, Guping
Huang, Feihe
author_sort Yu, Guocan
collection PubMed
description Due to the differences in the cavity size of the hosts and the charge and length of the guests, a cationic water-soluble pillar[6]arene (WP6) selectively complexes with ATP to form a stable 1 : 1 inclusion complex WP6⊃ATP. This host–guest complexation was utilized to efficiently inhibit the hydrolysis of ATP, arising from the existence of the hydrophobic cavity of WP6. A folic acid functionalized diblock copolymer (FA-PEG-b-PAA) was employed to PEGylate WP6 to endow the polyion complex (PIC) micelles with specific targeting ability, preferentially delivering WP6 to folate receptor over-expressing KB cell. This host–guest complexation was further used to block the efflux pump to transport anticancer drugs out of cells by cutting off the energy source, which enhanced the efficacy of the cancer chemotherapy of DOX·HCl towards drug resistant MCF-7/ADR cell. This supramolecular method provides an extremely distinct strategy to potentially overcome multidrug resistance (MDR).
format Online
Article
Text
id pubmed-6013913
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-60139132018-08-28 Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment Yu, Guocan Zhou, Jiong Shen, Jie Tang, Guping Huang, Feihe Chem Sci Chemistry Due to the differences in the cavity size of the hosts and the charge and length of the guests, a cationic water-soluble pillar[6]arene (WP6) selectively complexes with ATP to form a stable 1 : 1 inclusion complex WP6⊃ATP. This host–guest complexation was utilized to efficiently inhibit the hydrolysis of ATP, arising from the existence of the hydrophobic cavity of WP6. A folic acid functionalized diblock copolymer (FA-PEG-b-PAA) was employed to PEGylate WP6 to endow the polyion complex (PIC) micelles with specific targeting ability, preferentially delivering WP6 to folate receptor over-expressing KB cell. This host–guest complexation was further used to block the efflux pump to transport anticancer drugs out of cells by cutting off the energy source, which enhanced the efficacy of the cancer chemotherapy of DOX·HCl towards drug resistant MCF-7/ADR cell. This supramolecular method provides an extremely distinct strategy to potentially overcome multidrug resistance (MDR). Royal Society of Chemistry 2016-07-01 2016-03-02 /pmc/articles/PMC6013913/ /pubmed/30155051 http://dx.doi.org/10.1039/c6sc00531d Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Yu, Guocan
Zhou, Jiong
Shen, Jie
Tang, Guping
Huang, Feihe
Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment
title Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment
title_full Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment
title_fullStr Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment
title_full_unstemmed Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment
title_short Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment
title_sort cationic pillar[6]arene/atp host–guest recognition: selectivity, inhibition of atp hydrolysis, and application in multidrug resistance treatment
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013913/
https://www.ncbi.nlm.nih.gov/pubmed/30155051
http://dx.doi.org/10.1039/c6sc00531d
work_keys_str_mv AT yuguocan cationicpillar6areneatphostguestrecognitionselectivityinhibitionofatphydrolysisandapplicationinmultidrugresistancetreatment
AT zhoujiong cationicpillar6areneatphostguestrecognitionselectivityinhibitionofatphydrolysisandapplicationinmultidrugresistancetreatment
AT shenjie cationicpillar6areneatphostguestrecognitionselectivityinhibitionofatphydrolysisandapplicationinmultidrugresistancetreatment
AT tangguping cationicpillar6areneatphostguestrecognitionselectivityinhibitionofatphydrolysisandapplicationinmultidrugresistancetreatment
AT huangfeihe cationicpillar6areneatphostguestrecognitionselectivityinhibitionofatphydrolysisandapplicationinmultidrugresistancetreatment