Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity

AIMS: Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative stress enhances arterial thrombosis. This study investigated the effects of genetic Sirt3 deletion on a...

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Detalles Bibliográficos
Autores principales: Gaul, Daniel S, Weber, Julien, van Tits, Lambertus J, Sluka, Susanna, Pasterk, Lisa, Reiner, Martin F, Calatayud, Natacha, Lohmann, Christine, Klingenberg, Roland, Pahla, Jürgen, Vdovenko, Daria, Tanner, Felix C, Camici, Giovanni G, Eriksson, Urs, Auwerx, Johan, Mach, François, Windecker, Stephan, Rodondi, Nicolas, Lüscher, Thomas F, Winnik, Stephan, Matter, Christian M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014146/
https://www.ncbi.nlm.nih.gov/pubmed/29444200
http://dx.doi.org/10.1093/cvr/cvy036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014146/
https://www.ncbi.nlm.nih.gov/pubmed/29444200
http://dx.doi.org/10.1093/cvr/cvy036

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