Cargando…

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity

AIMS: Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative stress enhances arterial thrombosis. This study investigated the effects of genetic Sirt3 deletion on a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gaul, Daniel S, Weber, Julien, van Tits, Lambertus J, Sluka, Susanna, Pasterk, Lisa, Reiner, Martin F, Calatayud, Natacha, Lohmann, Christine, Klingenberg, Roland, Pahla, Jürgen, Vdovenko, Daria, Tanner, Felix C, Camici, Giovanni G, Eriksson, Urs, Auwerx, Johan, Mach, François, Windecker, Stephan, Rodondi, Nicolas, Lüscher, Thomas F, Winnik, Stephan, Matter, Christian M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014146/ https://www.ncbi.nlm.nih.gov/pubmed/29444200 http://dx.doi.org/10.1093/cvr/cvy036

Ejemplares similares

Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2
por: Winnik, Stephan, et al.
Publicado: (2016)

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development
por: Winnik, Stephan, et al.
Publicado: (2013)

The Sirt1 activator SRT3025 provides atheroprotection in Apoe(−/−) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
por: Miranda, Melroy X., et al.
Publicado: (2015)

Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity
por: Schäfer, Nicola, et al.
Publicado: (2013)

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice
por: Stein, Sokrates, et al.
Publicado: (2010)

Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome
por: Canivell, Silvia, et al.
Publicado: (2018)

Optimal Timing of Invasive Coronary Angiography following NSTEMI
por: Mahendiran, Thabo, et al.
Publicado: (2020)

Health utility indexes in patients with acute coronary syndromes
por: Gencer, Baris, et al.
Publicado: (2016)

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside
por: Winnik, Stephan, et al.
Publicado: (2015)

Eligibility for PCSK9 Inhibitors According to American College of Cardiology (ACC) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) Guidelines After Acute Coronary Syndromes
por: Gencer, Baris, et al.
Publicado: (2017)

Uptake and efficacy of a systematic intensive smoking cessation intervention using motivational interviewing for smokers hospitalised for an acute coronary syndrome: a multicentre before–after study with parallel group comparisons
por: Auer, Reto, et al.
Publicado: (2016)

Clinical impact of a structured secondary cardiovascular prevention program following acute coronary syndromes: A prospective multicenter healthcare intervention
por: Carballo, David, et al.
Publicado: (2019)

Cysteine‐Rich Angiogenic Inducer 61 Improves Prognostic Accuracy of GRACE (Global Registry of Acute Coronary Events) 2.0 Risk Score in Patients With Acute Coronary Syndromes
por: Klingenberg, Roland, et al.
Publicado: (2021)

Quality of Care after Acute Coronary Syndromes in a Prospective Cohort with Reasons for Non-Prescription of Recommended Medications
por: Auer, Reto, et al.
Publicado: (2014)

Non-Linear Relationship between Anti-Apolipoprotein A-1 IgGs and Cardiovascular Outcomes in Patients with Acute Coronary Syndromes
por: Vuilleumier, Nicolas, et al.
Publicado: (2019)

Association between self-reported motivation to quit smoking with effectiveness of smoking cessation intervention among patients hospitalized for acute coronary syndromes in Switzerland
por: Worni-Schudel, Inge, et al.
Publicado: (2021)

Best Poster Award – Third Prize: The Perilousness of Antidepressant Drugs in a Real-world Cohort of Patients with Acute Coronary Syndrome
por: Denegri, A, et al.
Publicado: (2020)

Effects of SARS-COV-2 infection on outcomes in patients hospitalized for acute cardiac conditions. A prospective, multicenter cohort study (Swiss Cardiovascular SARS-CoV-2 Consortium)
por: Koskinas, Konstantinos C., et al.
Publicado: (2023)

Diabetes and baseline glucose are associated with inflammation, left ventricular function and short- and long-term outcome in acute coronary syndromes: role of the novel biomarker Cyr 61
por: Winzap, Patric, et al.
Publicado: (2019)

Prognostic Value of SYNTAX Score II in Patients with Acute Coronary Syndromes Referred for Invasive Management: A Subanalysis from the SPUM and COMFORTABLE AMI Cohorts
por: Obeid, Slayman, et al.
Publicado: (2018)

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation
por: Winnik, Stephan, et al.
Publicado: (2011)

Occurrence and Impact of Time Delay to Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction
por: Shahin, Mohammady, et al.
Publicado: (2017)

Alternatively Spliced Tissue Factor Is Not Sufficient for Embryonic Development
por: Sluka, Susanna H. M., et al.
Publicado: (2014)

Incidence, Predictors, and Clinical Impact of Early Prasugrel Cessation in Patients With ST‐Elevation Myocardial Infarction
por: Koskinas, Konstantinos C., et al.
Publicado: (2018)

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
por: Stein, Sokrates, et al.
Publicado: (2010)

Microvesicles released from activated CD4(+) T cells alter microvascular endothelial cell function
por: Vdovenko, Daria, et al.
Publicado: (2022)

Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol
por: Laaksonen, Reijo, et al.
Publicado: (2016)

Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress
por: Yang, Kangmin, et al.
Publicado: (2023)

Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata
por: Brokopp, Chad E., et al.
Publicado: (2011)

Lifelong dietary omega-3 fatty acid suppresses thrombotic potential through gut microbiota alteration in aged mice
por: Saeedi Saravi, Seyed Soheil, et al.
Publicado: (2021)

Peripheral Blood Monocyte Sirt1 Expression Is Reduced in Patients with Coronary Artery Disease
por: Breitenstein, Alexander, et al.
Publicado: (2013)

Dual Role of Endothelial Nitric Oxide Synthase in Oxidized LDL-Induced, p66(Shc)-Mediated Oxidative Stress in Cultured Human Endothelial Cells
por: Shi, Yi, et al.
Publicado: (2014)

Interference between PARPs and SIRT1: a novel approach to healthy ageing?
por: CantÓ, Carles, et al.
Publicado: (2011)

Interleukin-1β Mediates Arterial Thrombus Formation via NET-Associated Tissue Factor
por: Liberale, Luca, et al.
Publicado: (2019)

Novel Blood Biomarkers for a Diagnostic Workup of Acute Aortic Dissection
por: Forrer, Anja, et al.
Publicado: (2021)

ApoE−/− PGC-1α−/− Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis
por: Stein, Sokrates, et al.
Publicado: (2010)

From abstract to impact in cardiovascular research: factors predicting publication and citation
por: Winnik, Stephan, et al.
Publicado: (2012)

Omega‐3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation
por: Baumgartner, Philipp, et al.
Publicado: (2023)

Rheumatoid arthritis and coronary atherosclerosis: two cousins engaging in a dangerous liaison
por: Klingenberg, Roland, et al.
Publicado: (2015)

Metabolic Characterization of a Sirt5 deficient mouse model
por: Yu, Jiujiu, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4oldd869b0oe2k4i7133baqmku