Cargando…

The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients

Background: There is limited information about oxidative stress and inflammation on the mortality of Chinese hemodialysis (HD) patients. Subjects and methods: A total of 177 HD patients and 35 healthy controls were enrolled. Their demographic information, clinical characteristics, oxidant and inflam...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhen, Yu, Chao, Li, Xin-hua, Deng, Bing-qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014340/
https://www.ncbi.nlm.nih.gov/pubmed/27767372
http://dx.doi.org/10.1080/0886022X.2016.1244078
_version_ 1783334218032480256
author Wang, Zhen
Yu, Chao
Li, Xin-hua
Deng, Bing-qing
author_facet Wang, Zhen
Yu, Chao
Li, Xin-hua
Deng, Bing-qing
author_sort Wang, Zhen
collection PubMed
description Background: There is limited information about oxidative stress and inflammation on the mortality of Chinese hemodialysis (HD) patients. Subjects and methods: A total of 177 HD patients and 35 healthy controls were enrolled. Their demographic information, clinical characteristics, oxidant and inflammation markers were compared. Multivariate Cox regression analysis was used to assess the risk factors for mortality. Results: Twenty-seven (15.3%) HD patients died during the one-year follow-up. The mean age, age ≥70 years, serum level of cardiac troponin T (cTnT), malondialdehyde (MDA) > 5 nmol/L, as well as CRP >10 mg/L and the level of interleukin (IL)-6 were significantly different between the nonsurvival and survival HD patients. Multivariate Cox's regression analysis identified age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in HD patients. Conclusions: Age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in Chinese HD patients. Elevated IL-6 level, instead of MDA, was predictive of poor outcome in Chinese hemodialysis patients.
format Online
Article
Text
id pubmed-6014340
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-60143402018-06-28 The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients Wang, Zhen Yu, Chao Li, Xin-hua Deng, Bing-qing Ren Fail Clinical Study Background: There is limited information about oxidative stress and inflammation on the mortality of Chinese hemodialysis (HD) patients. Subjects and methods: A total of 177 HD patients and 35 healthy controls were enrolled. Their demographic information, clinical characteristics, oxidant and inflammation markers were compared. Multivariate Cox regression analysis was used to assess the risk factors for mortality. Results: Twenty-seven (15.3%) HD patients died during the one-year follow-up. The mean age, age ≥70 years, serum level of cardiac troponin T (cTnT), malondialdehyde (MDA) > 5 nmol/L, as well as CRP >10 mg/L and the level of interleukin (IL)-6 were significantly different between the nonsurvival and survival HD patients. Multivariate Cox's regression analysis identified age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in HD patients. Conclusions: Age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in Chinese HD patients. Elevated IL-6 level, instead of MDA, was predictive of poor outcome in Chinese hemodialysis patients. Taylor & Francis 2016-10-21 /pmc/articles/PMC6014340/ /pubmed/27767372 http://dx.doi.org/10.1080/0886022X.2016.1244078 Text en © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/Licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Wang, Zhen
Yu, Chao
Li, Xin-hua
Deng, Bing-qing
The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients
title The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients
title_full The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients
title_fullStr The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients
title_full_unstemmed The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients
title_short The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients
title_sort prognostic value of oxidative stress and inflammation in chinese hemodialysis patients
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014340/
https://www.ncbi.nlm.nih.gov/pubmed/27767372
http://dx.doi.org/10.1080/0886022X.2016.1244078
work_keys_str_mv AT wangzhen theprognosticvalueofoxidativestressandinflammationinchinesehemodialysispatients
AT yuchao theprognosticvalueofoxidativestressandinflammationinchinesehemodialysispatients
AT lixinhua theprognosticvalueofoxidativestressandinflammationinchinesehemodialysispatients
AT dengbingqing theprognosticvalueofoxidativestressandinflammationinchinesehemodialysispatients
AT wangzhen prognosticvalueofoxidativestressandinflammationinchinesehemodialysispatients
AT yuchao prognosticvalueofoxidativestressandinflammationinchinesehemodialysispatients
AT lixinhua prognosticvalueofoxidativestressandinflammationinchinesehemodialysispatients
AT dengbingqing prognosticvalueofoxidativestressandinflammationinchinesehemodialysispatients