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The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients
Background: There is limited information about oxidative stress and inflammation on the mortality of Chinese hemodialysis (HD) patients. Subjects and methods: A total of 177 HD patients and 35 healthy controls were enrolled. Their demographic information, clinical characteristics, oxidant and inflam...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014340/ https://www.ncbi.nlm.nih.gov/pubmed/27767372 http://dx.doi.org/10.1080/0886022X.2016.1244078 |
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author | Wang, Zhen Yu, Chao Li, Xin-hua Deng, Bing-qing |
author_facet | Wang, Zhen Yu, Chao Li, Xin-hua Deng, Bing-qing |
author_sort | Wang, Zhen |
collection | PubMed |
description | Background: There is limited information about oxidative stress and inflammation on the mortality of Chinese hemodialysis (HD) patients. Subjects and methods: A total of 177 HD patients and 35 healthy controls were enrolled. Their demographic information, clinical characteristics, oxidant and inflammation markers were compared. Multivariate Cox regression analysis was used to assess the risk factors for mortality. Results: Twenty-seven (15.3%) HD patients died during the one-year follow-up. The mean age, age ≥70 years, serum level of cardiac troponin T (cTnT), malondialdehyde (MDA) > 5 nmol/L, as well as CRP >10 mg/L and the level of interleukin (IL)-6 were significantly different between the nonsurvival and survival HD patients. Multivariate Cox's regression analysis identified age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in HD patients. Conclusions: Age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in Chinese HD patients. Elevated IL-6 level, instead of MDA, was predictive of poor outcome in Chinese hemodialysis patients. |
format | Online Article Text |
id | pubmed-6014340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-60143402018-06-28 The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients Wang, Zhen Yu, Chao Li, Xin-hua Deng, Bing-qing Ren Fail Clinical Study Background: There is limited information about oxidative stress and inflammation on the mortality of Chinese hemodialysis (HD) patients. Subjects and methods: A total of 177 HD patients and 35 healthy controls were enrolled. Their demographic information, clinical characteristics, oxidant and inflammation markers were compared. Multivariate Cox regression analysis was used to assess the risk factors for mortality. Results: Twenty-seven (15.3%) HD patients died during the one-year follow-up. The mean age, age ≥70 years, serum level of cardiac troponin T (cTnT), malondialdehyde (MDA) > 5 nmol/L, as well as CRP >10 mg/L and the level of interleukin (IL)-6 were significantly different between the nonsurvival and survival HD patients. Multivariate Cox's regression analysis identified age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in HD patients. Conclusions: Age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in Chinese HD patients. Elevated IL-6 level, instead of MDA, was predictive of poor outcome in Chinese hemodialysis patients. Taylor & Francis 2016-10-21 /pmc/articles/PMC6014340/ /pubmed/27767372 http://dx.doi.org/10.1080/0886022X.2016.1244078 Text en © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/Licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Wang, Zhen Yu, Chao Li, Xin-hua Deng, Bing-qing The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients |
title | The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients |
title_full | The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients |
title_fullStr | The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients |
title_full_unstemmed | The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients |
title_short | The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients |
title_sort | prognostic value of oxidative stress and inflammation in chinese hemodialysis patients |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014340/ https://www.ncbi.nlm.nih.gov/pubmed/27767372 http://dx.doi.org/10.1080/0886022X.2016.1244078 |
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