Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket

[Image: see text] Sirtuins (SIRTs) are NAD-dependent deacylases, known to be involved in a variety of pathophysiological processes and thus remain promising therapeutic targets for further validation. Previously, we reported a novel thienopyrimidinone SIRT2 inhibitor with good potency and excellent...

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Detalles Bibliográficos
Autores principales: Sundriyal, Sandeep, Moniot, Sébastien, Mahmud, Zimam, Yao, Shang, Di Fruscia, Paolo, Reynolds, Christopher R., Dexter, David T., Sternberg, Michael J. E., Lam, Eric W.-F., Steegborn, Clemens, Fuchter, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014686/
https://www.ncbi.nlm.nih.gov/pubmed/28135086
http://dx.doi.org/10.1021/acs.jmedchem.6b01690

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