Enhanced Delta-Notch Lateral Inhibition Model Incorporating Intracellular Notch Heterogeneity and Tension-Dependent Rate of Delta-Notch Binding that Reproduces Sprouting Angiogenesis Patterns

Endothelial cells adopt unique cell fates during sprouting angiogenesis, differentiating into tip or stalk cells. The fate selection process is directed by Delta-Notch lateral inhibition pathway. Classical Delta-Notch models produce a spatial pattern of tip cells separated by a single stalk cell, or...

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Detalles Bibliográficos
Autores principales: Koon, Yen Ling, Zhang, Songjing, Rahmat, Muhammad Bakhait, Koh, Cheng Gee, Chiam, Keng-Hwee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015056/
https://www.ncbi.nlm.nih.gov/pubmed/29934586
http://dx.doi.org/10.1038/s41598-018-27645-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015056/
https://www.ncbi.nlm.nih.gov/pubmed/29934586
http://dx.doi.org/10.1038/s41598-018-27645-1

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