Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling

Intracellular signals triggered by DNA breakage flow through proteins containing BRCT (BRCA1 C-terminal) domains. This family, comprising 23 conserved phosphopeptide-binding modules in man, is inaccessible to small-molecule chemical inhibitors. Here, we develop Bractoppin, a drug-like inhibitor of p...

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Detalles Bibliográficos
Autores principales: Periasamy, Jayaprakash, Kurdekar, Vadiraj, Jasti, Subbarao, Nijaguna, Mamatha B., Boggaram, Sanjana, Hurakadli, Manjunath A., Raina, Dhruv, Kurup, Lokavya Meenakshi, Chintha, Chetan, Manjunath, Kavyashree, Goyal, Aneesh, Sadasivam, Gayathri, Bharatham, Kavitha, Padigaru, Muralidhara, Potluri, Vijay, Venkitaraman, Ashok R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015222/
https://www.ncbi.nlm.nih.gov/pubmed/29606576
http://dx.doi.org/10.1016/j.chembiol.2018.02.012

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