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Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study
BACKGROUND: Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated. METHODS AND RESULTS: Data from the fourth survey (1994–1995) of the Tromsø Study (Norway) were us...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015294/ https://www.ncbi.nlm.nih.gov/pubmed/29674336 http://dx.doi.org/10.1161/JAHA.117.008414 |
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author | Ball, Jocasta Løchen, Maja‐Lisa Wilsgaard, Tom Schirmer, Henrik Hopstock, Laila A. Morseth, Bente Mathiesen, Ellisiv B. Njølstad, Inger Tiwari, Sweta Sharashova, Ekaterina |
author_facet | Ball, Jocasta Løchen, Maja‐Lisa Wilsgaard, Tom Schirmer, Henrik Hopstock, Laila A. Morseth, Bente Mathiesen, Ellisiv B. Njølstad, Inger Tiwari, Sweta Sharashova, Ekaterina |
author_sort | Ball, Jocasta |
collection | PubMed |
description | BACKGROUND: Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated. METHODS AND RESULTS: Data from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF risk. To analyze the influence of BMI changes on AF risk, data from individuals who attended the third and fourth study surveys were used. AF diagnosis was derived from record linkage and end point adjudication. Cox regression analysis was conducted using fractional polynomials of BMI and BMI change with models adjusted for age, baseline BMI (change analyses), risk factors, comorbidities, and antihypertensive medications. Data were available for 24 799 individuals from the fourth survey (mean age, 45.5±14.2 years; 52.9% women). Over 15.7±5.5 years, 811 women (6.2%) and 918 men (7.9%) developed AF. In men, lower BMI decreased AF risk and higher BMI increased risk (hazard ratios [95% confidence intervals] for BMI 18 or 40 kg/m(2) compared with 23 kg/m(2) were 0.75 [0.70–0.81] and 4.42 [3.00–6.53], respectively). The same pattern was identified in women. Two surveys were attended by 14 652 individuals. In men and women, a decrease in BMI over time was associated with decreased AF risk and an increase in BMI was associated with increased AF risk. CONCLUSIONS: Within a population cohort, BMI was positively associated with AF risk. Change in BMI over time influenced AF risk in both men and women. |
format | Online Article Text |
id | pubmed-6015294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60152942018-07-05 Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study Ball, Jocasta Løchen, Maja‐Lisa Wilsgaard, Tom Schirmer, Henrik Hopstock, Laila A. Morseth, Bente Mathiesen, Ellisiv B. Njølstad, Inger Tiwari, Sweta Sharashova, Ekaterina J Am Heart Assoc Original Research BACKGROUND: Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated. METHODS AND RESULTS: Data from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF risk. To analyze the influence of BMI changes on AF risk, data from individuals who attended the third and fourth study surveys were used. AF diagnosis was derived from record linkage and end point adjudication. Cox regression analysis was conducted using fractional polynomials of BMI and BMI change with models adjusted for age, baseline BMI (change analyses), risk factors, comorbidities, and antihypertensive medications. Data were available for 24 799 individuals from the fourth survey (mean age, 45.5±14.2 years; 52.9% women). Over 15.7±5.5 years, 811 women (6.2%) and 918 men (7.9%) developed AF. In men, lower BMI decreased AF risk and higher BMI increased risk (hazard ratios [95% confidence intervals] for BMI 18 or 40 kg/m(2) compared with 23 kg/m(2) were 0.75 [0.70–0.81] and 4.42 [3.00–6.53], respectively). The same pattern was identified in women. Two surveys were attended by 14 652 individuals. In men and women, a decrease in BMI over time was associated with decreased AF risk and an increase in BMI was associated with increased AF risk. CONCLUSIONS: Within a population cohort, BMI was positively associated with AF risk. Change in BMI over time influenced AF risk in both men and women. John Wiley and Sons Inc. 2018-04-19 /pmc/articles/PMC6015294/ /pubmed/29674336 http://dx.doi.org/10.1161/JAHA.117.008414 Text en © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Ball, Jocasta Løchen, Maja‐Lisa Wilsgaard, Tom Schirmer, Henrik Hopstock, Laila A. Morseth, Bente Mathiesen, Ellisiv B. Njølstad, Inger Tiwari, Sweta Sharashova, Ekaterina Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
title | Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
title_full | Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
title_fullStr | Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
title_full_unstemmed | Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
title_short | Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study |
title_sort | sex differences in the impact of body mass index on the risk of future atrial fibrillation: insights from the longitudinal population‐based tromsø study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015294/ https://www.ncbi.nlm.nih.gov/pubmed/29674336 http://dx.doi.org/10.1161/JAHA.117.008414 |
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