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Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis

BACKGROUND: Left ventricular diastolic dysfunction (DD) is common, particularly in women and older individuals, and it is associated with adverse cardiovascular outcomes. We evaluated the impact of age‐ and sex‐specific diagnostic criteria on the assessment of DD in the community‐based Framingham He...

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Autores principales: Nayor, Matthew, Cooper, Leroy L., Enserro, Danielle M., Xanthakis, Vanessa, Larson, Martin G., Benjamin, Emelia J., Aragam, Jayashri, Mitchell, Gary F., Vasan, Ramachandran S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015390/
https://www.ncbi.nlm.nih.gov/pubmed/29858363
http://dx.doi.org/10.1161/JAHA.117.008291
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author Nayor, Matthew
Cooper, Leroy L.
Enserro, Danielle M.
Xanthakis, Vanessa
Larson, Martin G.
Benjamin, Emelia J.
Aragam, Jayashri
Mitchell, Gary F.
Vasan, Ramachandran S.
author_facet Nayor, Matthew
Cooper, Leroy L.
Enserro, Danielle M.
Xanthakis, Vanessa
Larson, Martin G.
Benjamin, Emelia J.
Aragam, Jayashri
Mitchell, Gary F.
Vasan, Ramachandran S.
author_sort Nayor, Matthew
collection PubMed
description BACKGROUND: Left ventricular diastolic dysfunction (DD) is common, particularly in women and older individuals, and it is associated with adverse cardiovascular outcomes. We evaluated the impact of age‐ and sex‐specific diagnostic criteria on the assessment of DD in the community‐based Framingham Heart Study. METHODS AND RESULTS: We estimated age‐ and sex‐specific reference limits for echocardiographic measures of DD in a healthy reference subsample (N=2355, mean age 44 years, 66% women). The prevalence, correlates, and association with future cardiovascular disease were compared for DD using age‐ and sex‐specific versus single cut point reference limits in a broad sample (N=6102, mean age 50 years, 56% women). Using age‐ and sex‐specific criteria, DD was present in ≈25% to 30% of individuals across age groups, and it was directly associated with a number of modifiable risk factors. In contrast, with single cut point criteria, age was the primary determinant of DD. During follow‐up (mean 7.9±2.2 years), incident cardiovascular disease occurred in 213 of 5770 individuals. Using age‐ and sex‐specific criteria, mild and moderate‐severe DD were associated with 50% (95% confidence interval, 1.09–2.05) and 65% (95% confidence interval, 1.14–2.38) higher incidences of cardiovascular disease, respectively, in age‐ and sex‐adjusted analyses. With single cut point criteria, moderate‐severe DD (hazard ratio, 1.66; 95% confidence interval, 1.05–2.61), but not mild DD (hazard ratio, 0.94; 95% confidence interval, 0.63–1.40), was associated with incident cardiovascular disease. CONCLUSIONS: Age‐ and sex‐specific reference limits may result in DD assessments that are less dependent on age, more robustly related to modifiable risk factors, and are more closely associated with incident cardiovascular disease.
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spelling pubmed-60153902018-07-05 Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis Nayor, Matthew Cooper, Leroy L. Enserro, Danielle M. Xanthakis, Vanessa Larson, Martin G. Benjamin, Emelia J. Aragam, Jayashri Mitchell, Gary F. Vasan, Ramachandran S. J Am Heart Assoc Original Research BACKGROUND: Left ventricular diastolic dysfunction (DD) is common, particularly in women and older individuals, and it is associated with adverse cardiovascular outcomes. We evaluated the impact of age‐ and sex‐specific diagnostic criteria on the assessment of DD in the community‐based Framingham Heart Study. METHODS AND RESULTS: We estimated age‐ and sex‐specific reference limits for echocardiographic measures of DD in a healthy reference subsample (N=2355, mean age 44 years, 66% women). The prevalence, correlates, and association with future cardiovascular disease were compared for DD using age‐ and sex‐specific versus single cut point reference limits in a broad sample (N=6102, mean age 50 years, 56% women). Using age‐ and sex‐specific criteria, DD was present in ≈25% to 30% of individuals across age groups, and it was directly associated with a number of modifiable risk factors. In contrast, with single cut point criteria, age was the primary determinant of DD. During follow‐up (mean 7.9±2.2 years), incident cardiovascular disease occurred in 213 of 5770 individuals. Using age‐ and sex‐specific criteria, mild and moderate‐severe DD were associated with 50% (95% confidence interval, 1.09–2.05) and 65% (95% confidence interval, 1.14–2.38) higher incidences of cardiovascular disease, respectively, in age‐ and sex‐adjusted analyses. With single cut point criteria, moderate‐severe DD (hazard ratio, 1.66; 95% confidence interval, 1.05–2.61), but not mild DD (hazard ratio, 0.94; 95% confidence interval, 0.63–1.40), was associated with incident cardiovascular disease. CONCLUSIONS: Age‐ and sex‐specific reference limits may result in DD assessments that are less dependent on age, more robustly related to modifiable risk factors, and are more closely associated with incident cardiovascular disease. John Wiley and Sons Inc. 2018-06-01 /pmc/articles/PMC6015390/ /pubmed/29858363 http://dx.doi.org/10.1161/JAHA.117.008291 Text en © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Nayor, Matthew
Cooper, Leroy L.
Enserro, Danielle M.
Xanthakis, Vanessa
Larson, Martin G.
Benjamin, Emelia J.
Aragam, Jayashri
Mitchell, Gary F.
Vasan, Ramachandran S.
Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis
title Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis
title_full Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis
title_fullStr Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis
title_full_unstemmed Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis
title_short Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis
title_sort left ventricular diastolic dysfunction in the community: impact of diagnostic criteria on the burden, correlates, and prognosis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015390/
https://www.ncbi.nlm.nih.gov/pubmed/29858363
http://dx.doi.org/10.1161/JAHA.117.008291
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