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Infrequent false positive [(18)F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques

BACKGROUND: The performance of [(18)F]flutemetamol amyloid PET against histopathological standards of truth was the subject of our recent article in Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (2017;9:25–34). MAIN BODY: This viewpoint article addresses infrequently obs...

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Autores principales: Ikonomovic, Milos D., Fantoni, Enrico R., Farrar, Gill, Salloway, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015459/
https://www.ncbi.nlm.nih.gov/pubmed/29935545
http://dx.doi.org/10.1186/s13195-018-0387-6
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author Ikonomovic, Milos D.
Fantoni, Enrico R.
Farrar, Gill
Salloway, Stephen
author_facet Ikonomovic, Milos D.
Fantoni, Enrico R.
Farrar, Gill
Salloway, Stephen
author_sort Ikonomovic, Milos D.
collection PubMed
description BACKGROUND: The performance of [(18)F]flutemetamol amyloid PET against histopathological standards of truth was the subject of our recent article in Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (2017;9:25–34). MAIN BODY: This viewpoint article addresses infrequently observed discordance between visual [(18)F]flutemetamol PET image readings and histopathology based solely on neuritic plaque assessment by CERAD criteria, which is resolved by assessing both neuritic and diffuse plaques and/or brain atrophy. CONCLUSION: [(18)F]flutemetamol PET signal corresponds predominantly to neuritic plaque pathology but is also influenced by the presence of diffuse plaques. This could allow for detection of diffuse amyloid deposits in the early stages of AD dementia, particularly in the striatum where diffuse amyloid is most commonly observed.
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spelling pubmed-60154592018-07-05 Infrequent false positive [(18)F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques Ikonomovic, Milos D. Fantoni, Enrico R. Farrar, Gill Salloway, Stephen Alzheimers Res Ther Viewpoint BACKGROUND: The performance of [(18)F]flutemetamol amyloid PET against histopathological standards of truth was the subject of our recent article in Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (2017;9:25–34). MAIN BODY: This viewpoint article addresses infrequently observed discordance between visual [(18)F]flutemetamol PET image readings and histopathology based solely on neuritic plaque assessment by CERAD criteria, which is resolved by assessing both neuritic and diffuse plaques and/or brain atrophy. CONCLUSION: [(18)F]flutemetamol PET signal corresponds predominantly to neuritic plaque pathology but is also influenced by the presence of diffuse plaques. This could allow for detection of diffuse amyloid deposits in the early stages of AD dementia, particularly in the striatum where diffuse amyloid is most commonly observed. BioMed Central 2018-06-23 /pmc/articles/PMC6015459/ /pubmed/29935545 http://dx.doi.org/10.1186/s13195-018-0387-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Viewpoint
Ikonomovic, Milos D.
Fantoni, Enrico R.
Farrar, Gill
Salloway, Stephen
Infrequent false positive [(18)F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques
title Infrequent false positive [(18)F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques
title_full Infrequent false positive [(18)F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques
title_fullStr Infrequent false positive [(18)F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques
title_full_unstemmed Infrequent false positive [(18)F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques
title_short Infrequent false positive [(18)F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques
title_sort infrequent false positive [(18)f]flutemetamol pet signal is resolved by combined histological assessment of neuritic and diffuse plaques
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015459/
https://www.ncbi.nlm.nih.gov/pubmed/29935545
http://dx.doi.org/10.1186/s13195-018-0387-6
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