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Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study
Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for the risk of pSS in patients with CP. In this study, we evaluated the risk of pSS from CP exposure in a nationwide population-based cohort...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015484/ https://www.ncbi.nlm.nih.gov/pubmed/29942713 http://dx.doi.org/10.7717/peerj.5109 |
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author | Lin, Tai-Chen Tseng, Chien-Fang Wang, Yu-Hsun Yu, Hui-Chieh Chang, Yu-Chao |
author_facet | Lin, Tai-Chen Tseng, Chien-Fang Wang, Yu-Hsun Yu, Hui-Chieh Chang, Yu-Chao |
author_sort | Lin, Tai-Chen |
collection | PubMed |
description | Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for the risk of pSS in patients with CP. In this study, we evaluated the risk of pSS from CP exposure in a nationwide population-based cohort study in Taiwan. We studied the claims data of Taiwanese population from 2001 to 2012. We identified 76,765 patients with CP from the National Health Insurance Database in Taiwan. We also selected 76,765 controls that were randomly frequency matched by age, sex, and index year from the general population. We analyzed the risk of pSS by using Cox proportional hazards regression models including sex, age, and comorbidities. In this study, 76,765 patients with CP (mean age: 40.8 years) and 76,765 controls (mean age: 41.0 years) were followed-up for 8.54 and 8.49 years, respectively. A total of 869 cases of pSS were identified in CP cohort and 483 cases in non-CP cohort. Multivariate Cox regression analysis indicated that the incidence rate of pSS was significantly higher in CP cohort than those who in non-CP cohort (adjusted HR: 1.79, 95% CI [1.60–2.00]). Taken together, this nationwide retrospective cohort study demonstrated that the risk of pSS was significantly higher in patients with CP than in the general population. The association between CP and pSS was significant in the female group. |
format | Online Article Text |
id | pubmed-6015484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60154842018-06-25 Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study Lin, Tai-Chen Tseng, Chien-Fang Wang, Yu-Hsun Yu, Hui-Chieh Chang, Yu-Chao PeerJ Dentistry Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for the risk of pSS in patients with CP. In this study, we evaluated the risk of pSS from CP exposure in a nationwide population-based cohort study in Taiwan. We studied the claims data of Taiwanese population from 2001 to 2012. We identified 76,765 patients with CP from the National Health Insurance Database in Taiwan. We also selected 76,765 controls that were randomly frequency matched by age, sex, and index year from the general population. We analyzed the risk of pSS by using Cox proportional hazards regression models including sex, age, and comorbidities. In this study, 76,765 patients with CP (mean age: 40.8 years) and 76,765 controls (mean age: 41.0 years) were followed-up for 8.54 and 8.49 years, respectively. A total of 869 cases of pSS were identified in CP cohort and 483 cases in non-CP cohort. Multivariate Cox regression analysis indicated that the incidence rate of pSS was significantly higher in CP cohort than those who in non-CP cohort (adjusted HR: 1.79, 95% CI [1.60–2.00]). Taken together, this nationwide retrospective cohort study demonstrated that the risk of pSS was significantly higher in patients with CP than in the general population. The association between CP and pSS was significant in the female group. PeerJ Inc. 2018-06-20 /pmc/articles/PMC6015484/ /pubmed/29942713 http://dx.doi.org/10.7717/peerj.5109 Text en © 2018 Lin et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Dentistry Lin, Tai-Chen Tseng, Chien-Fang Wang, Yu-Hsun Yu, Hui-Chieh Chang, Yu-Chao Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study |
title | Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study |
title_full | Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study |
title_fullStr | Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study |
title_full_unstemmed | Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study |
title_short | Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study |
title_sort | patients with chronic periodontitis present increased risk for primary sjögren syndrome: a nationwide population-based cohort study |
topic | Dentistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015484/ https://www.ncbi.nlm.nih.gov/pubmed/29942713 http://dx.doi.org/10.7717/peerj.5109 |
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