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Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study

Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for the risk of pSS in patients with CP. In this study, we evaluated the risk of pSS from CP exposure in a nationwide population-based cohort...

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Autores principales: Lin, Tai-Chen, Tseng, Chien-Fang, Wang, Yu-Hsun, Yu, Hui-Chieh, Chang, Yu-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015484/
https://www.ncbi.nlm.nih.gov/pubmed/29942713
http://dx.doi.org/10.7717/peerj.5109
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author Lin, Tai-Chen
Tseng, Chien-Fang
Wang, Yu-Hsun
Yu, Hui-Chieh
Chang, Yu-Chao
author_facet Lin, Tai-Chen
Tseng, Chien-Fang
Wang, Yu-Hsun
Yu, Hui-Chieh
Chang, Yu-Chao
author_sort Lin, Tai-Chen
collection PubMed
description Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for the risk of pSS in patients with CP. In this study, we evaluated the risk of pSS from CP exposure in a nationwide population-based cohort study in Taiwan. We studied the claims data of Taiwanese population from 2001 to 2012. We identified 76,765 patients with CP from the National Health Insurance Database in Taiwan. We also selected 76,765 controls that were randomly frequency matched by age, sex, and index year from the general population. We analyzed the risk of pSS by using Cox proportional hazards regression models including sex, age, and comorbidities. In this study, 76,765 patients with CP (mean age: 40.8 years) and 76,765 controls (mean age: 41.0 years) were followed-up for 8.54 and 8.49 years, respectively. A total of 869 cases of pSS were identified in CP cohort and 483 cases in non-CP cohort. Multivariate Cox regression analysis indicated that the incidence rate of pSS was significantly higher in CP cohort than those who in non-CP cohort (adjusted HR: 1.79, 95% CI [1.60–2.00]). Taken together, this nationwide retrospective cohort study demonstrated that the risk of pSS was significantly higher in patients with CP than in the general population. The association between CP and pSS was significant in the female group.
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spelling pubmed-60154842018-06-25 Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study Lin, Tai-Chen Tseng, Chien-Fang Wang, Yu-Hsun Yu, Hui-Chieh Chang, Yu-Chao PeerJ Dentistry Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for the risk of pSS in patients with CP. In this study, we evaluated the risk of pSS from CP exposure in a nationwide population-based cohort study in Taiwan. We studied the claims data of Taiwanese population from 2001 to 2012. We identified 76,765 patients with CP from the National Health Insurance Database in Taiwan. We also selected 76,765 controls that were randomly frequency matched by age, sex, and index year from the general population. We analyzed the risk of pSS by using Cox proportional hazards regression models including sex, age, and comorbidities. In this study, 76,765 patients with CP (mean age: 40.8 years) and 76,765 controls (mean age: 41.0 years) were followed-up for 8.54 and 8.49 years, respectively. A total of 869 cases of pSS were identified in CP cohort and 483 cases in non-CP cohort. Multivariate Cox regression analysis indicated that the incidence rate of pSS was significantly higher in CP cohort than those who in non-CP cohort (adjusted HR: 1.79, 95% CI [1.60–2.00]). Taken together, this nationwide retrospective cohort study demonstrated that the risk of pSS was significantly higher in patients with CP than in the general population. The association between CP and pSS was significant in the female group. PeerJ Inc. 2018-06-20 /pmc/articles/PMC6015484/ /pubmed/29942713 http://dx.doi.org/10.7717/peerj.5109 Text en © 2018 Lin et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Dentistry
Lin, Tai-Chen
Tseng, Chien-Fang
Wang, Yu-Hsun
Yu, Hui-Chieh
Chang, Yu-Chao
Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study
title Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study
title_full Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study
title_fullStr Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study
title_full_unstemmed Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study
title_short Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study
title_sort patients with chronic periodontitis present increased risk for primary sjögren syndrome: a nationwide population-based cohort study
topic Dentistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015484/
https://www.ncbi.nlm.nih.gov/pubmed/29942713
http://dx.doi.org/10.7717/peerj.5109
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