Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes

Monoamine oxidase (MAO) inhibitors ameliorate contractile function in diabetic animals, but the mechanisms remain unknown. Equally elusive is the interplay between the cardiomyocyte alterations induced by hyperglycemia and the accompanying inflammation. Here we show that exposure of primary cardiomy...

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Detalles Bibliográficos
Autores principales: Deshwal, Soni, Forkink, Marleen, Hu, Chou-Hui, Buonincontri, Guido, Antonucci, Salvatore, Di Sante, Moises, Murphy, Michael P, Paolocci, Nazareno, Mochly-Rosen, Daria, Krieg, Thomas, Di Lisa, Fabio, Kaludercic, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015497/
https://www.ncbi.nlm.nih.gov/pubmed/29459772
http://dx.doi.org/10.1038/s41418-018-0071-1

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