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Convergent pathways in Parkinson’s disease
Preferential degeneration of dopamine neurons (DAn) in the midbrain represents the principal hallmark of Parkinson’s disease (PD). It has been hypothesized that major contributors to DAn vulnerability lie in their unique cellular physiology and architecture, which make them particularly susceptible...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015598/ https://www.ncbi.nlm.nih.gov/pubmed/29063175 http://dx.doi.org/10.1007/s00441-017-2700-2 |
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author | Cherubini, Marta Wade-Martins, Richard |
author_facet | Cherubini, Marta Wade-Martins, Richard |
author_sort | Cherubini, Marta |
collection | PubMed |
description | Preferential degeneration of dopamine neurons (DAn) in the midbrain represents the principal hallmark of Parkinson’s disease (PD). It has been hypothesized that major contributors to DAn vulnerability lie in their unique cellular physiology and architecture, which make them particularly susceptible to stress factors. Here, we report a concise overview of some of the cell mechanisms that may exacerbate DAn sensitivity and loss in PD. In particular, we highlight how defective protein sorting and clearance, endoplasmic reticulum stress, calcium dyshomeostasis and intracellular trafficking converge to contribute synergistically to neuronal dysfunction in PD pathogenesis. |
format | Online Article Text |
id | pubmed-6015598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-60155982018-07-09 Convergent pathways in Parkinson’s disease Cherubini, Marta Wade-Martins, Richard Cell Tissue Res Review Preferential degeneration of dopamine neurons (DAn) in the midbrain represents the principal hallmark of Parkinson’s disease (PD). It has been hypothesized that major contributors to DAn vulnerability lie in their unique cellular physiology and architecture, which make them particularly susceptible to stress factors. Here, we report a concise overview of some of the cell mechanisms that may exacerbate DAn sensitivity and loss in PD. In particular, we highlight how defective protein sorting and clearance, endoplasmic reticulum stress, calcium dyshomeostasis and intracellular trafficking converge to contribute synergistically to neuronal dysfunction in PD pathogenesis. Springer Berlin Heidelberg 2017-10-23 2018 /pmc/articles/PMC6015598/ /pubmed/29063175 http://dx.doi.org/10.1007/s00441-017-2700-2 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Cherubini, Marta Wade-Martins, Richard Convergent pathways in Parkinson’s disease |
title | Convergent pathways in Parkinson’s disease |
title_full | Convergent pathways in Parkinson’s disease |
title_fullStr | Convergent pathways in Parkinson’s disease |
title_full_unstemmed | Convergent pathways in Parkinson’s disease |
title_short | Convergent pathways in Parkinson’s disease |
title_sort | convergent pathways in parkinson’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015598/ https://www.ncbi.nlm.nih.gov/pubmed/29063175 http://dx.doi.org/10.1007/s00441-017-2700-2 |
work_keys_str_mv | AT cherubinimarta convergentpathwaysinparkinsonsdisease AT wademartinsrichard convergentpathwaysinparkinsonsdisease |