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Neurodegeneration and the ordered assembly of α-synuclein
In 2017, it was 200 years since James Parkinson published ‘An Essay on the Shaking Palsy’ and 20 years since α-synuclein aggregation came to the fore. In 1998, multiple system atrophy joined Parkinson’s disease and dementia with Lewy bodies as the third major synucleinopathy. Here, we describe the w...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015613/ https://www.ncbi.nlm.nih.gov/pubmed/29119326 http://dx.doi.org/10.1007/s00441-017-2706-9 |
| _version_ | 1783334436438278144 |
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| author | Spillantini, Maria Grazia Goedert, Michel |
| author_facet | Spillantini, Maria Grazia Goedert, Michel |
| author_sort | Spillantini, Maria Grazia |
| collection | PubMed |
| description | In 2017, it was 200 years since James Parkinson published ‘An Essay on the Shaking Palsy’ and 20 years since α-synuclein aggregation came to the fore. In 1998, multiple system atrophy joined Parkinson’s disease and dementia with Lewy bodies as the third major synucleinopathy. Here, we describe the work that led to the identification of α-synuclein in Lewy bodies, Lewy neurites and Papp–Lantos bodies. We also review some of the findings reported since 1997. |
| format | Online Article Text |
| id | pubmed-6015613 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Springer Berlin Heidelberg |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-60156132018-07-09 Neurodegeneration and the ordered assembly of α-synuclein Spillantini, Maria Grazia Goedert, Michel Cell Tissue Res Review In 2017, it was 200 years since James Parkinson published ‘An Essay on the Shaking Palsy’ and 20 years since α-synuclein aggregation came to the fore. In 1998, multiple system atrophy joined Parkinson’s disease and dementia with Lewy bodies as the third major synucleinopathy. Here, we describe the work that led to the identification of α-synuclein in Lewy bodies, Lewy neurites and Papp–Lantos bodies. We also review some of the findings reported since 1997. Springer Berlin Heidelberg 2017-11-08 2018 /pmc/articles/PMC6015613/ /pubmed/29119326 http://dx.doi.org/10.1007/s00441-017-2706-9 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| spellingShingle | Review Spillantini, Maria Grazia Goedert, Michel Neurodegeneration and the ordered assembly of α-synuclein |
| title | Neurodegeneration and the ordered assembly of α-synuclein |
| title_full | Neurodegeneration and the ordered assembly of α-synuclein |
| title_fullStr | Neurodegeneration and the ordered assembly of α-synuclein |
| title_full_unstemmed | Neurodegeneration and the ordered assembly of α-synuclein |
| title_short | Neurodegeneration and the ordered assembly of α-synuclein |
| title_sort | neurodegeneration and the ordered assembly of α-synuclein |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015613/ https://www.ncbi.nlm.nih.gov/pubmed/29119326 http://dx.doi.org/10.1007/s00441-017-2706-9 |
| work_keys_str_mv | AT spillantinimariagrazia neurodegenerationandtheorderedassemblyofasynuclein AT goedertmichel neurodegenerationandtheorderedassemblyofasynuclein |