Intermittent convection-enhanced delivery of GDNF into rhesus monkey putamen: absence of local or cerebellar toxicity

Glial cell line-derived neurotrophic factor (GDNF) has demonstrated neurorestorative and neuroprotective effects in rodent and nonhuman primate models of Parkinson’s disease. However, continuous intraputamenal infusion of GDNF (100 µg/day) resulted in multifocal cerebellar Purkinje cell loss in a 6-...

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Detalles Bibliográficos
Autores principales: Luz, Matthias, Allen, Philip C., Bringas, John, Boiko, Chris, Stockinger, Diane E., Nikula, Kristen J., Lewis, Owen, Woolley, Max, Fibiger, H. Christian, Bankiewicz, Krystof, Mohr, Erich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015623/
https://www.ncbi.nlm.nih.gov/pubmed/29785638
http://dx.doi.org/10.1007/s00204-018-2222-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015623/
https://www.ncbi.nlm.nih.gov/pubmed/29785638
http://dx.doi.org/10.1007/s00204-018-2222-z

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