Pulmonary Arterial Hypertension and Endothelial Dysfunction Is Linked to NADPH Oxidase-Derived Superoxide Formation in Venous Thrombosis and Pulmonary Embolism in Mice

Pulmonary embolism (PE) results from deep vein thrombosis (DVT) and can lead to chronic thromboembolic pulmonary hypertension (CTEPH) involving vascular dysfunction. Mechanisms are incompletely understood, in part due to lack of mouse models. We induced PE in C57BL/6 mice by intravenous injection of...

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Detalles Bibliográficos
Autores principales: Brandt, Moritz, Giokoglu, Eleni, Garlapati, Venkata, Bochenek, Madgalena L., Molitor, Michael, Hobohm, Lukas, Schönfelder, Tanja, Münzel, Thomas, Kossmann, Sabine, Karbach, Susanne H., Schäfer, Katrin, Wenzel, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015670/
https://www.ncbi.nlm.nih.gov/pubmed/29983855
http://dx.doi.org/10.1155/2018/1860513

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