Personalizing Radiation Treatment Delivery in the Management of Breast Cancer

Long-term data establishes the efficacy of radiotherapy in the adjuvant management of breast cancer. New dose and fractionation schemas have evolved and are available, each with unique risks and rewards. Current efforts are ongoing to tailor radiotherapy to the unique biology of breast cancer. In th...

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Detalles Bibliográficos
Autores principales: Ahmed, Kamran A., Grass, G. Daniel, Orman, Amber G., Liveringhouse, Casey, Montejo, Michael E., Soliman, Hatem H., Han, Heather S., Czerniecki, Brian J., Torres-Roca, Javier F., Diaz, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015692/
https://www.ncbi.nlm.nih.gov/pubmed/29984003
http://dx.doi.org/10.1155/2018/6729802
Descripción
Sumario:Long-term data establishes the efficacy of radiotherapy in the adjuvant management of breast cancer. New dose and fractionation schemas have evolved and are available, each with unique risks and rewards. Current efforts are ongoing to tailor radiotherapy to the unique biology of breast cancer. In this review, we discuss our efforts to personalize radiotherapy dosing using genomic data and the implications for future clinical trials. We also explore immune mechanisms that may contribute to a tumor's unique radiation sensitivity or resistance.

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