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Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain

Aging is the predominant risk factor for both genetic and sporadic Parkinson’s disease (PD). The majority of PD cases are nonfamilial, and the connection between aging and PD-associated genes is not well understood. Haploinsufficiency of the GBA gene, leading to a reduction in glucocerebrosidase (GC...

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Detalles Bibliográficos
Autores principales:	Hallett, Penelope J., Huebecker, Mylene, Brekk, Oeystein R., Moloney, Elizabeth B., Rocha, Emily M., Priestman, David A., Platt, Frances M., Isacson, Ole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015735/ https://www.ncbi.nlm.nih.gov/pubmed/29735433 http://dx.doi.org/10.1016/j.neurobiolaging.2018.02.028

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