Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Rhinoviruses are the pathogens most often responsible for the common cold, and are a frequent cause of exacerbations in asthma, chronic obstructive pulmonary disease and cystic fibrosis. Here we report discovery of IMP-1088, a picomolar dual inhibitor of the human N-myristoyltransferases NMT1 and NM...

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Detalles Bibliográficos
Autores principales: Mousnier, Aurélie, Bell, Andrew S., Swieboda, Dawid P., Morales-Sanfrutos, Julia, Pérez-Dorado, Inmaculada, Brannigan, James A., Newman, Joseph, Ritzefeld, Markus, Hutton, Jennie A., Guedán, Anabel, Asfor, Amin A., Robinson, Sean W., Hopkins-Navratilova, Iva, Wilkinson, Anthony J., Johnston, Sebastian L., Leatherbarrow, Robin J., Tuthill, Tobias J., Solari, Roberto, Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015761/
https://www.ncbi.nlm.nih.gov/pubmed/29760414
http://dx.doi.org/10.1038/s41557-018-0039-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015761/
https://www.ncbi.nlm.nih.gov/pubmed/29760414
http://dx.doi.org/10.1038/s41557-018-0039-2

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