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Role of osteopontin in bone remodeling and orthodontic tooth movement: a review
In this review, most of the known and postulated mechanisms of osteopontin (OPN) and its role in bone remodeling and orthodontic tooth movement are discussed based on available literature. OPN, a multifunctional protein, is considered crucial for bone remodeling, biomineralization, and periodontal r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015792/ https://www.ncbi.nlm.nih.gov/pubmed/29938297 http://dx.doi.org/10.1186/s40510-018-0216-2 |
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author | Singh, Amarjot Gill, Gurveen Kaur, Harsimrat Amhmed, Mohamed Jakhu, Harpal |
author_facet | Singh, Amarjot Gill, Gurveen Kaur, Harsimrat Amhmed, Mohamed Jakhu, Harpal |
author_sort | Singh, Amarjot |
collection | PubMed |
description | In this review, most of the known and postulated mechanisms of osteopontin (OPN) and its role in bone remodeling and orthodontic tooth movement are discussed based on available literature. OPN, a multifunctional protein, is considered crucial for bone remodeling, biomineralization, and periodontal remodeling during mechanical tension and stress (orthodontic tooth movement). It contributes to bone remodeling by promoting osteoclastogenesis and osteoclast activity through CD44- and αvβ3-mediated cell signaling. Further, it has a definitive role in bone remodeling by the formation of podosomes, osteoclast survival, and osteoclast motility. OPN has been shown to have a regulatory effect on hydroxyapatite crystal (HAP) growth and potently inhibits the mineralization of osteoblast cultures in a phosphate-dependent manner. Bone remodeling is vital for orthodontic tooth movement. Significant compressive and tensional forces on the periodontium induce the signaling pathways mediated by various osteogenic genes including OPN, bone sialoprotein, Osterix, and osteocalcin. The signaling pathways involved in the regulation of OPN and its effect on the periodontal tissues during orthodontic tooth movement are further discussed in this review. A limited number of studies have suggested the use of OPN as a biomarker to assess orthodontic treatment. Furthermore, the association of single nucleotide polymorphisms (SNPs) in OPN coding gene Spp1 with orthodontically induced root resorption remains largely unexplored. Accordingly, future research directions for OPN are outlined in this review. |
format | Online Article Text |
id | pubmed-6015792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-60157922018-07-06 Role of osteopontin in bone remodeling and orthodontic tooth movement: a review Singh, Amarjot Gill, Gurveen Kaur, Harsimrat Amhmed, Mohamed Jakhu, Harpal Prog Orthod Review In this review, most of the known and postulated mechanisms of osteopontin (OPN) and its role in bone remodeling and orthodontic tooth movement are discussed based on available literature. OPN, a multifunctional protein, is considered crucial for bone remodeling, biomineralization, and periodontal remodeling during mechanical tension and stress (orthodontic tooth movement). It contributes to bone remodeling by promoting osteoclastogenesis and osteoclast activity through CD44- and αvβ3-mediated cell signaling. Further, it has a definitive role in bone remodeling by the formation of podosomes, osteoclast survival, and osteoclast motility. OPN has been shown to have a regulatory effect on hydroxyapatite crystal (HAP) growth and potently inhibits the mineralization of osteoblast cultures in a phosphate-dependent manner. Bone remodeling is vital for orthodontic tooth movement. Significant compressive and tensional forces on the periodontium induce the signaling pathways mediated by various osteogenic genes including OPN, bone sialoprotein, Osterix, and osteocalcin. The signaling pathways involved in the regulation of OPN and its effect on the periodontal tissues during orthodontic tooth movement are further discussed in this review. A limited number of studies have suggested the use of OPN as a biomarker to assess orthodontic treatment. Furthermore, the association of single nucleotide polymorphisms (SNPs) in OPN coding gene Spp1 with orthodontically induced root resorption remains largely unexplored. Accordingly, future research directions for OPN are outlined in this review. Springer Berlin Heidelberg 2018-06-25 /pmc/articles/PMC6015792/ /pubmed/29938297 http://dx.doi.org/10.1186/s40510-018-0216-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Singh, Amarjot Gill, Gurveen Kaur, Harsimrat Amhmed, Mohamed Jakhu, Harpal Role of osteopontin in bone remodeling and orthodontic tooth movement: a review |
title | Role of osteopontin in bone remodeling and orthodontic tooth movement: a review |
title_full | Role of osteopontin in bone remodeling and orthodontic tooth movement: a review |
title_fullStr | Role of osteopontin in bone remodeling and orthodontic tooth movement: a review |
title_full_unstemmed | Role of osteopontin in bone remodeling and orthodontic tooth movement: a review |
title_short | Role of osteopontin in bone remodeling and orthodontic tooth movement: a review |
title_sort | role of osteopontin in bone remodeling and orthodontic tooth movement: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015792/ https://www.ncbi.nlm.nih.gov/pubmed/29938297 http://dx.doi.org/10.1186/s40510-018-0216-2 |
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