The Role of Advanced Glycation End Products in Diabetic Vascular Complications

In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complicatio...

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Detalles Bibliográficos
Autores principales: Rhee, Sang Youl, Kim, Young Seol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2018
Materias:
Sulwon Lecture 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015964/
https://www.ncbi.nlm.nih.gov/pubmed/29885110
http://dx.doi.org/10.4093/dmj.2017.0105
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author Rhee, Sang Youl
Kim, Young Seol
author_facet Rhee, Sang Youl
Kim, Young Seol
author_sort Rhee, Sang Youl
collection PubMed
description In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications.
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spelling pubmed-60159642018-06-29 The Role of Advanced Glycation End Products in Diabetic Vascular Complications Rhee, Sang Youl Kim, Young Seol Diabetes Metab J Sulwon Lecture 2017 In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications. Korean Diabetes Association 2018-06 2018-05-31 /pmc/articles/PMC6015964/ /pubmed/29885110 http://dx.doi.org/10.4093/dmj.2017.0105 Text en Copyright © 2018 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Sulwon Lecture 2017
Rhee, Sang Youl
Kim, Young Seol
The Role of Advanced Glycation End Products in Diabetic Vascular Complications
title The Role of Advanced Glycation End Products in Diabetic Vascular Complications
title_full The Role of Advanced Glycation End Products in Diabetic Vascular Complications
title_fullStr The Role of Advanced Glycation End Products in Diabetic Vascular Complications
title_full_unstemmed The Role of Advanced Glycation End Products in Diabetic Vascular Complications
title_short The Role of Advanced Glycation End Products in Diabetic Vascular Complications
title_sort role of advanced glycation end products in diabetic vascular complications
topic Sulwon Lecture 2017
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015964/
https://www.ncbi.nlm.nih.gov/pubmed/29885110
http://dx.doi.org/10.4093/dmj.2017.0105
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