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Thio-Linked UDP–Peptide Conjugates as O-GlcNAc Transferase Inhibitors

[Image: see text] O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc post-translational modification on the nucleocytoplasmic proteome. We report the development of S-linked UDP–peptide conjugates as potent bisubstrate OGT inhibitors. These compounds were assem...

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Detalles Bibliográficos
Autores principales:	Rafie, Karim, Gorelik, Andrii, Trapannone, Riccardo, Borodkin, Vladimir S., van Aalten, Daan M. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016062/ https://www.ncbi.nlm.nih.gov/pubmed/29723473 http://dx.doi.org/10.1021/acs.bioconjchem.8b00194

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