Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer

Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of oncogenic molecules (including Smoothened, KRAS, EGFR, and PDGFR), their precise role in cancer remains unclear. We have interrogated the role of cilia in acquired and de novo...

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Detalles Bibliográficos
Autores principales: Jenks, Andrew D., Vyse, Simon, Wong, Jocelyn P., Kostaras, Eleftherios, Keller, Deborah, Burgoyne, Thomas, Shoemark, Amelia, Tsalikis, Athanasios, de la Roche, Maike, Michaelis, Martin, Cinatl, Jindrich, Huang, Paul H., Tanos, Barbara E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016080/
https://www.ncbi.nlm.nih.gov/pubmed/29874589
http://dx.doi.org/10.1016/j.celrep.2018.05.016

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