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Gastroesophageal Reflux Characteristics and Patterns in Patients with Idiopathic Subglottic Stenosis

INTRODUCTION: Idiopathic subglottic stenosis represents a spectrum of subglottic disease without a clear underlying cause. Prior studies have implicated a pathogenic role of gastroesophageal reflux disease in idiopathic subglottic stenosis. The aim of this study was to examine the presence and patte...

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Autores principales: Fang, Hongfei, Codipilly, Don C., Ravi, Karthik, Ekbom, Dale C., Kasperbauer, Jan L., Halland, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016176/
https://www.ncbi.nlm.nih.gov/pubmed/29991945
http://dx.doi.org/10.1155/2018/8563697
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author Fang, Hongfei
Codipilly, Don C.
Ravi, Karthik
Ekbom, Dale C.
Kasperbauer, Jan L.
Halland, Magnus
author_facet Fang, Hongfei
Codipilly, Don C.
Ravi, Karthik
Ekbom, Dale C.
Kasperbauer, Jan L.
Halland, Magnus
author_sort Fang, Hongfei
collection PubMed
description INTRODUCTION: Idiopathic subglottic stenosis represents a spectrum of subglottic disease without a clear underlying cause. Prior studies have implicated a pathogenic role of gastroesophageal reflux disease in idiopathic subglottic stenosis. The aim of this study was to examine the presence and pattern of gastroesophageal reflux in a large cohort of patients with idiopathic subglottic stenosis at a tertiary referral center. METHODS: We performed a retrospective review of patients with idiopathic subglottic stenosis from January 2010 to December 2016 who had undergone combined pH impedance testing. Patients with prior gastric or esophageal surgery were excluded. Data obtained included esophageal acid exposure times, number of reflux events, patient position during reflux events (defined as upright, supine, or mixed), body mass index, and the presence of proton pump inhibitor therapy. RESULTS: 159 patients with the idiopathic subglottic stenosis were identified, of whom 41 had undergone esophageal pH impedance testing. 40 (97.6%) were women, with a mean age of 54.8 (range 31–79) years and BMI of 31.0 (range 17–55). Overall, 19 (46.3%) patients were found to reflux as confirmed by abnormal esophageal acid exposure or abnormal number of reflux events. 15 of the 19 patients with reflux had predominantly upright gastroesophageal reflux disease, whereas 2 had supine and 2 mixed reflux. DISCUSSION: In patients with idiopathic subglottic stenosis who underwent evaluation by combined pH impedance, close to half were found to have gastroesophageal reflux disease. The majority of gastroesophageal reflux occurred while the patients were in the upright position.
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spelling pubmed-60161762018-07-10 Gastroesophageal Reflux Characteristics and Patterns in Patients with Idiopathic Subglottic Stenosis Fang, Hongfei Codipilly, Don C. Ravi, Karthik Ekbom, Dale C. Kasperbauer, Jan L. Halland, Magnus Gastroenterol Res Pract Research Article INTRODUCTION: Idiopathic subglottic stenosis represents a spectrum of subglottic disease without a clear underlying cause. Prior studies have implicated a pathogenic role of gastroesophageal reflux disease in idiopathic subglottic stenosis. The aim of this study was to examine the presence and pattern of gastroesophageal reflux in a large cohort of patients with idiopathic subglottic stenosis at a tertiary referral center. METHODS: We performed a retrospective review of patients with idiopathic subglottic stenosis from January 2010 to December 2016 who had undergone combined pH impedance testing. Patients with prior gastric or esophageal surgery were excluded. Data obtained included esophageal acid exposure times, number of reflux events, patient position during reflux events (defined as upright, supine, or mixed), body mass index, and the presence of proton pump inhibitor therapy. RESULTS: 159 patients with the idiopathic subglottic stenosis were identified, of whom 41 had undergone esophageal pH impedance testing. 40 (97.6%) were women, with a mean age of 54.8 (range 31–79) years and BMI of 31.0 (range 17–55). Overall, 19 (46.3%) patients were found to reflux as confirmed by abnormal esophageal acid exposure or abnormal number of reflux events. 15 of the 19 patients with reflux had predominantly upright gastroesophageal reflux disease, whereas 2 had supine and 2 mixed reflux. DISCUSSION: In patients with idiopathic subglottic stenosis who underwent evaluation by combined pH impedance, close to half were found to have gastroesophageal reflux disease. The majority of gastroesophageal reflux occurred while the patients were in the upright position. Hindawi 2018-06-11 /pmc/articles/PMC6016176/ /pubmed/29991945 http://dx.doi.org/10.1155/2018/8563697 Text en Copyright © 2018 Hongfei Fang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fang, Hongfei
Codipilly, Don C.
Ravi, Karthik
Ekbom, Dale C.
Kasperbauer, Jan L.
Halland, Magnus
Gastroesophageal Reflux Characteristics and Patterns in Patients with Idiopathic Subglottic Stenosis
title Gastroesophageal Reflux Characteristics and Patterns in Patients with Idiopathic Subglottic Stenosis
title_full Gastroesophageal Reflux Characteristics and Patterns in Patients with Idiopathic Subglottic Stenosis
title_fullStr Gastroesophageal Reflux Characteristics and Patterns in Patients with Idiopathic Subglottic Stenosis
title_full_unstemmed Gastroesophageal Reflux Characteristics and Patterns in Patients with Idiopathic Subglottic Stenosis
title_short Gastroesophageal Reflux Characteristics and Patterns in Patients with Idiopathic Subglottic Stenosis
title_sort gastroesophageal reflux characteristics and patterns in patients with idiopathic subglottic stenosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016176/
https://www.ncbi.nlm.nih.gov/pubmed/29991945
http://dx.doi.org/10.1155/2018/8563697
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