CRISPR Screen Reveals that EHEC’s T3SS and Shiga Toxin Rely on Shared Host Factors for Infection

Enterohemorrhagic Escherichia coli (EHEC) has two critical virulence factors—a type III secretion system (T3SS) and Shiga toxins (Stxs)—that are required for the pathogen to colonize the intestine and cause diarrheal disease. Here, we carried out a genome-wide CRISPR/Cas9 (clustered regularly inters...

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Detalles Bibliográficos
Autores principales: Pacheco, Alline R., Lazarus, Jacob E., Sit, Brandon, Schmieder, Stefanie, Lencer, Wayne I., Blondel, Carlos J., Doench, John G., Davis, Brigid M., Waldor, Matthew K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016243/
https://www.ncbi.nlm.nih.gov/pubmed/29921669
http://dx.doi.org/10.1128/mBio.01003-18

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