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Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis

BACKGROUND AND AIMS: Recently, the abnormal expression of FoxM1 has been found in many malignant tumors. However, the clinicopathological and prognostic value of FoxM1 expression in hepatocellular carcinoma (HCC) patients remains controversial. We conducted a meta-analysis to establish the relations...

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Autores principales: Liang, Chaojie, Zhao, Jingyang, Ge, Hua, Li, Guangming, Wu, Jixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016270/
https://www.ncbi.nlm.nih.gov/pubmed/29950861
http://dx.doi.org/10.2147/OTT.S155541
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author Liang, Chaojie
Zhao, Jingyang
Ge, Hua
Li, Guangming
Wu, Jixiang
author_facet Liang, Chaojie
Zhao, Jingyang
Ge, Hua
Li, Guangming
Wu, Jixiang
author_sort Liang, Chaojie
collection PubMed
description BACKGROUND AND AIMS: Recently, the abnormal expression of FoxM1 has been found in many malignant tumors. However, the clinicopathological and prognostic value of FoxM1 expression in hepatocellular carcinoma (HCC) patients remains controversial. We conducted a meta-analysis to establish the relationship between FoxM1 expression and the clinicopathological features and prognostic value in patients with HCC. METHODS: An electronic search for relevant articles was conducted according to a set of criteria in the PubMed, Cochrane Library, Web of Science, EMBASE, Chinese CNKI and Chinese WanFang databases. The correlation data between FoxM1 expression and clinicopathological features and survival outcomes were analyzed. Pooled odds ratios (ORs) and hazard ratios (HRs) with 95% CIs were calculated using STATA14.2. RESULTS: A total of 14 studies comprising of 2,036 patients were enrolled in this meta-analysis. The results showed that FoxM1 expression was related to the incidence, tumor size (>5 cm), vascular invasion, differentiation and TNM stage. Moreover, overexpression of FoxM1 indicated a poor 3- and 5-year overall survival rate (OS) and recurrence-free survival rate (disease-free survival rate). CONCLUSION: Our meta-analysis indicated that FoxM1 expression was associated with incidence, tumor size (>5 cm), vascular invasion, differentiation and TNM stage. Accordingly, FoxM1 may be a reliable prognostic biomarker for patients with HCC. However, additional high-quality studies are still needed to further support these findings.
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spelling pubmed-60162702018-06-27 Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis Liang, Chaojie Zhao, Jingyang Ge, Hua Li, Guangming Wu, Jixiang Onco Targets Ther Original Research BACKGROUND AND AIMS: Recently, the abnormal expression of FoxM1 has been found in many malignant tumors. However, the clinicopathological and prognostic value of FoxM1 expression in hepatocellular carcinoma (HCC) patients remains controversial. We conducted a meta-analysis to establish the relationship between FoxM1 expression and the clinicopathological features and prognostic value in patients with HCC. METHODS: An electronic search for relevant articles was conducted according to a set of criteria in the PubMed, Cochrane Library, Web of Science, EMBASE, Chinese CNKI and Chinese WanFang databases. The correlation data between FoxM1 expression and clinicopathological features and survival outcomes were analyzed. Pooled odds ratios (ORs) and hazard ratios (HRs) with 95% CIs were calculated using STATA14.2. RESULTS: A total of 14 studies comprising of 2,036 patients were enrolled in this meta-analysis. The results showed that FoxM1 expression was related to the incidence, tumor size (>5 cm), vascular invasion, differentiation and TNM stage. Moreover, overexpression of FoxM1 indicated a poor 3- and 5-year overall survival rate (OS) and recurrence-free survival rate (disease-free survival rate). CONCLUSION: Our meta-analysis indicated that FoxM1 expression was associated with incidence, tumor size (>5 cm), vascular invasion, differentiation and TNM stage. Accordingly, FoxM1 may be a reliable prognostic biomarker for patients with HCC. However, additional high-quality studies are still needed to further support these findings. Dove Medical Press 2018-06-19 /pmc/articles/PMC6016270/ /pubmed/29950861 http://dx.doi.org/10.2147/OTT.S155541 Text en © 2018 Liang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Liang, Chaojie
Zhao, Jingyang
Ge, Hua
Li, Guangming
Wu, Jixiang
Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis
title Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis
title_full Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis
title_fullStr Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis
title_full_unstemmed Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis
title_short Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis
title_sort clinicopathological and prognostic significance of foxm1 in hepatocellular carcinoma patients: a meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016270/
https://www.ncbi.nlm.nih.gov/pubmed/29950861
http://dx.doi.org/10.2147/OTT.S155541
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