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Prognostic value of miR-17-5p in cancers: a meta-analysis
BACKGROUND: Studies have shown that miR-17-5p plays an important role in the development of cancer. The aim of this meta-analysis was to quantitatively analyze the association of miR-17-5p with prognosis in various cancers. MATERIALS AND METHODS: We searched the PubMed, EMBASE, Web of Science, and C...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016279/ https://www.ncbi.nlm.nih.gov/pubmed/29950859 http://dx.doi.org/10.2147/OTT.S150340 |
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author | Kong, Weihao Cheng, Yusheng Liang, Hao Chen, Qiangxing Xiao, Cuicui Li, Kun Huang, Zenan Zhang, Jian |
author_facet | Kong, Weihao Cheng, Yusheng Liang, Hao Chen, Qiangxing Xiao, Cuicui Li, Kun Huang, Zenan Zhang, Jian |
author_sort | Kong, Weihao |
collection | PubMed |
description | BACKGROUND: Studies have shown that miR-17-5p plays an important role in the development of cancer. The aim of this meta-analysis was to quantitatively analyze the association of miR-17-5p with prognosis in various cancers. MATERIALS AND METHODS: We searched the PubMed, EMBASE, Web of Science, and Cochrane library databases for relevant studies through August 2017. The prognostic data and clinico-pathological features of overall survival (OS) and disease-free survival (DFS) were extracted to investigate the association between miR-17-5p expression and tumor prognosis. In addition, odds ratios (ORs) were used to assess the correlations between miR-17-5p expression and clinicopathological characteristics. RESULTS: A total of ten studies were incorporated into this systematic review, and we found that high miR-17-5p expression can predict poor OS for malignancies (combined hazard ratio [HR]=1.87; 95% confidence interval [CI], 1.37–2.55; P=0.000) as well as poor DFS (combined HR=1.60; 95% CI, 1.05–2.44; P=0.027). Further subgroup analyses suggested that high miR-17-5p expression was related to poor OS in Asian patients (combined HR=1.92; 95% CI, 1.37–2.71; P=0.000) and the serum/plasma sample source subgroup (combined HR=2.13; 95% CI, 1.36–3.31; P=0.001). The combined OR indicated that the expression of miR-17-5p was associated with lymph node invasion (OR=1.28; 95% CI, 1.05–1.56; P=0.016) and venous invasion (OR=1.92; 95% CI, 1.40–2.63; P=0.000). CONCLUSION: Elevated expression of miR-17-5p suggested a poor prognosis in cancer patients and may serve as a new tumor marker to monitor cancer development and progression. |
format | Online Article Text |
id | pubmed-6016279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60162792018-06-27 Prognostic value of miR-17-5p in cancers: a meta-analysis Kong, Weihao Cheng, Yusheng Liang, Hao Chen, Qiangxing Xiao, Cuicui Li, Kun Huang, Zenan Zhang, Jian Onco Targets Ther Original Research BACKGROUND: Studies have shown that miR-17-5p plays an important role in the development of cancer. The aim of this meta-analysis was to quantitatively analyze the association of miR-17-5p with prognosis in various cancers. MATERIALS AND METHODS: We searched the PubMed, EMBASE, Web of Science, and Cochrane library databases for relevant studies through August 2017. The prognostic data and clinico-pathological features of overall survival (OS) and disease-free survival (DFS) were extracted to investigate the association between miR-17-5p expression and tumor prognosis. In addition, odds ratios (ORs) were used to assess the correlations between miR-17-5p expression and clinicopathological characteristics. RESULTS: A total of ten studies were incorporated into this systematic review, and we found that high miR-17-5p expression can predict poor OS for malignancies (combined hazard ratio [HR]=1.87; 95% confidence interval [CI], 1.37–2.55; P=0.000) as well as poor DFS (combined HR=1.60; 95% CI, 1.05–2.44; P=0.027). Further subgroup analyses suggested that high miR-17-5p expression was related to poor OS in Asian patients (combined HR=1.92; 95% CI, 1.37–2.71; P=0.000) and the serum/plasma sample source subgroup (combined HR=2.13; 95% CI, 1.36–3.31; P=0.001). The combined OR indicated that the expression of miR-17-5p was associated with lymph node invasion (OR=1.28; 95% CI, 1.05–1.56; P=0.016) and venous invasion (OR=1.92; 95% CI, 1.40–2.63; P=0.000). CONCLUSION: Elevated expression of miR-17-5p suggested a poor prognosis in cancer patients and may serve as a new tumor marker to monitor cancer development and progression. Dove Medical Press 2018-06-19 /pmc/articles/PMC6016279/ /pubmed/29950859 http://dx.doi.org/10.2147/OTT.S150340 Text en © 2018 Kong et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Kong, Weihao Cheng, Yusheng Liang, Hao Chen, Qiangxing Xiao, Cuicui Li, Kun Huang, Zenan Zhang, Jian Prognostic value of miR-17-5p in cancers: a meta-analysis |
title | Prognostic value of miR-17-5p in cancers: a meta-analysis |
title_full | Prognostic value of miR-17-5p in cancers: a meta-analysis |
title_fullStr | Prognostic value of miR-17-5p in cancers: a meta-analysis |
title_full_unstemmed | Prognostic value of miR-17-5p in cancers: a meta-analysis |
title_short | Prognostic value of miR-17-5p in cancers: a meta-analysis |
title_sort | prognostic value of mir-17-5p in cancers: a meta-analysis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016279/ https://www.ncbi.nlm.nih.gov/pubmed/29950859 http://dx.doi.org/10.2147/OTT.S150340 |
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