Cargando…
Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells
Tissue-resident memory T cells (T(RM)) persist in peripheral tissues for long periods of time in the absence of antigenic stimulation. Upon re-encounter with cognate antigen, T(RM) trigger an immediate immune response at the local tissue microenvironment and provide the first line of host defense. T...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016524/ https://www.ncbi.nlm.nih.gov/pubmed/29967608 http://dx.doi.org/10.3389/fimmu.2018.01347 |
_version_ | 1783334582596141056 |
---|---|
author | Pan, Youdong Kupper, Thomas S. |
author_facet | Pan, Youdong Kupper, Thomas S. |
author_sort | Pan, Youdong |
collection | PubMed |
description | Tissue-resident memory T cells (T(RM)) persist in peripheral tissues for long periods of time in the absence of antigenic stimulation. Upon re-encounter with cognate antigen, T(RM) trigger an immediate immune response at the local tissue microenvironment and provide the first line of host defense. T(RM) have been reported to play significant roles in host antimicrobial infection, cancer immunotherapy, and pathogenesis of a number of human autoimmune diseases, such as psoriasis, vitiligo, and atopic dermatitis. T(RM) display a distinct gene transcriptome with unique gene expression profiles related to cellular metabolism that is different from naive T cells (T(N)), central memory T cells (T(CM)), and effector memory T cells (T(EM)). Skin CD8(+) T(RM) upregulate expression of genes associated with lipid uptake and metabolism and utilize mitochondria fatty acid β-oxidation to support their long-term survival (longevity) and function. In this review, we will summarize the recent progresses in the metabolic programming of T(RM) and will also discuss the potential to target the unique metabolic pathways of T(RM) to treat T(RM)-mediated diseases. |
format | Online Article Text |
id | pubmed-6016524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60165242018-07-02 Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells Pan, Youdong Kupper, Thomas S. Front Immunol Immunology Tissue-resident memory T cells (T(RM)) persist in peripheral tissues for long periods of time in the absence of antigenic stimulation. Upon re-encounter with cognate antigen, T(RM) trigger an immediate immune response at the local tissue microenvironment and provide the first line of host defense. T(RM) have been reported to play significant roles in host antimicrobial infection, cancer immunotherapy, and pathogenesis of a number of human autoimmune diseases, such as psoriasis, vitiligo, and atopic dermatitis. T(RM) display a distinct gene transcriptome with unique gene expression profiles related to cellular metabolism that is different from naive T cells (T(N)), central memory T cells (T(CM)), and effector memory T cells (T(EM)). Skin CD8(+) T(RM) upregulate expression of genes associated with lipid uptake and metabolism and utilize mitochondria fatty acid β-oxidation to support their long-term survival (longevity) and function. In this review, we will summarize the recent progresses in the metabolic programming of T(RM) and will also discuss the potential to target the unique metabolic pathways of T(RM) to treat T(RM)-mediated diseases. Frontiers Media S.A. 2018-06-18 /pmc/articles/PMC6016524/ /pubmed/29967608 http://dx.doi.org/10.3389/fimmu.2018.01347 Text en Copyright © 2018 Pan and Kupper. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Pan, Youdong Kupper, Thomas S. Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells |
title | Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells |
title_full | Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells |
title_fullStr | Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells |
title_full_unstemmed | Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells |
title_short | Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells |
title_sort | metabolic reprogramming and longevity of tissue-resident memory t cells |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016524/ https://www.ncbi.nlm.nih.gov/pubmed/29967608 http://dx.doi.org/10.3389/fimmu.2018.01347 |
work_keys_str_mv | AT panyoudong metabolicreprogrammingandlongevityoftissueresidentmemorytcells AT kupperthomass metabolicreprogrammingandlongevityoftissueresidentmemorytcells |