Cargando…

Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells

Tissue-resident memory T cells (T(RM)) persist in peripheral tissues for long periods of time in the absence of antigenic stimulation. Upon re-encounter with cognate antigen, T(RM) trigger an immediate immune response at the local tissue microenvironment and provide the first line of host defense. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Youdong, Kupper, Thomas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016524/
https://www.ncbi.nlm.nih.gov/pubmed/29967608
http://dx.doi.org/10.3389/fimmu.2018.01347
_version_ 1783334582596141056
author Pan, Youdong
Kupper, Thomas S.
author_facet Pan, Youdong
Kupper, Thomas S.
author_sort Pan, Youdong
collection PubMed
description Tissue-resident memory T cells (T(RM)) persist in peripheral tissues for long periods of time in the absence of antigenic stimulation. Upon re-encounter with cognate antigen, T(RM) trigger an immediate immune response at the local tissue microenvironment and provide the first line of host defense. T(RM) have been reported to play significant roles in host antimicrobial infection, cancer immunotherapy, and pathogenesis of a number of human autoimmune diseases, such as psoriasis, vitiligo, and atopic dermatitis. T(RM) display a distinct gene transcriptome with unique gene expression profiles related to cellular metabolism that is different from naive T cells (T(N)), central memory T cells (T(CM)), and effector memory T cells (T(EM)). Skin CD8(+) T(RM) upregulate expression of genes associated with lipid uptake and metabolism and utilize mitochondria fatty acid β-oxidation to support their long-term survival (longevity) and function. In this review, we will summarize the recent progresses in the metabolic programming of T(RM) and will also discuss the potential to target the unique metabolic pathways of T(RM) to treat T(RM)-mediated diseases.
format Online
Article
Text
id pubmed-6016524
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-60165242018-07-02 Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells Pan, Youdong Kupper, Thomas S. Front Immunol Immunology Tissue-resident memory T cells (T(RM)) persist in peripheral tissues for long periods of time in the absence of antigenic stimulation. Upon re-encounter with cognate antigen, T(RM) trigger an immediate immune response at the local tissue microenvironment and provide the first line of host defense. T(RM) have been reported to play significant roles in host antimicrobial infection, cancer immunotherapy, and pathogenesis of a number of human autoimmune diseases, such as psoriasis, vitiligo, and atopic dermatitis. T(RM) display a distinct gene transcriptome with unique gene expression profiles related to cellular metabolism that is different from naive T cells (T(N)), central memory T cells (T(CM)), and effector memory T cells (T(EM)). Skin CD8(+) T(RM) upregulate expression of genes associated with lipid uptake and metabolism and utilize mitochondria fatty acid β-oxidation to support their long-term survival (longevity) and function. In this review, we will summarize the recent progresses in the metabolic programming of T(RM) and will also discuss the potential to target the unique metabolic pathways of T(RM) to treat T(RM)-mediated diseases. Frontiers Media S.A. 2018-06-18 /pmc/articles/PMC6016524/ /pubmed/29967608 http://dx.doi.org/10.3389/fimmu.2018.01347 Text en Copyright © 2018 Pan and Kupper. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Pan, Youdong
Kupper, Thomas S.
Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells
title Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells
title_full Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells
title_fullStr Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells
title_full_unstemmed Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells
title_short Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells
title_sort metabolic reprogramming and longevity of tissue-resident memory t cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016524/
https://www.ncbi.nlm.nih.gov/pubmed/29967608
http://dx.doi.org/10.3389/fimmu.2018.01347
work_keys_str_mv AT panyoudong metabolicreprogrammingandlongevityoftissueresidentmemorytcells
AT kupperthomass metabolicreprogrammingandlongevityoftissueresidentmemorytcells