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Cigarette smoke up‐regulates PDE3 and PDE4 to decrease cAMP in airway cells

BACKGROUND AND PURPOSE: cAMP is a central second messenger that broadly regulates cell function and can underpin pathophysiology. In chronic obstructive pulmonary disease, a lung disease primarily provoked by cigarette smoke (CS), the activation of cAMP‐dependent pathways, via inhibition of hydrolyz...

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Detalles Bibliográficos
Autores principales:	Zuo, Haoxiao, Han, Bing, Poppinga, Wilfred J, Ringnalda, Lennard, Kistemaker, Loes E M, Halayko, Andrew J, Gosens, Reinoud, Nikolaev, Viacheslav O, Schmidt, Martina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016635/ https://www.ncbi.nlm.nih.gov/pubmed/29722436 http://dx.doi.org/10.1111/bph.14347

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