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Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain

BACKGROUND: High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. HMGB1 interacts with toll-like receptors (TLRs) but contradictory evidence regarding its identity as a TLR2 ligand persists. The aim...

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Detalles Bibliográficos
Autores principales:	Aucott, Hannah, Sowinska, Agnieszka, Harris, Helena Erlandsson, Lundback, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016865/ https://www.ncbi.nlm.nih.gov/pubmed/30134807 http://dx.doi.org/10.1186/s10020-018-0021-x

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