Cargando…

Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine

BACKGROUND: Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases (CVDs). Stachydrine (STA) is an active component in Chinese motherwort Leonurus heterophyllus sweet, which has been widely used for gynecological and cardiovascular disorders. This study is aimed to exa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Xinya, Zhang, Zihui, Wang, Xinfeng, Luo, Zhenyu, Lai, Baochang, Xiao, Lei, Wang, Nanping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016886/ https://www.ncbi.nlm.nih.gov/pubmed/30134790 http://dx.doi.org/10.1186/s10020-018-0010-0

Ejemplares similares

Oleanolic acid ameliorates high glucose-induced endothelial dysfunction via PPARδ activation
por: Zhang, Zihui, et al.
Publicado: (2017)

Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
por: Janaszak-Jasiecka, Anna, et al.
Publicado: (2023)

mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling
por: Wang, Yiying, et al.
Publicado: (2022)

Glutathionylation Mediates Angiotensin II–Induced eNOS Uncoupling, Amplifying NADPH Oxidase‐Dependent Endothelial Dysfunction
por: Galougahi, Keyvan Karimi, et al.
Publicado: (2014)

Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling
por: Zhu, Cuicui, et al.
Publicado: (2017)

Ursolic acid prevents doxorubicin‐induced cardiac toxicity in mice through eNOS activation and inhibition of eNOS uncoupling
por: Mu, Haiman, et al.
Publicado: (2019)

Lack of Endothelial α1AMPK Reverses the Vascular Protective Effects of Exercise by Causing eNOS Uncoupling
por: Jansen, Thomas, et al.
Publicado: (2021)

Multiple inducers of endothelial NOS (eNOS) dysfunction in sickle cell disease
por: Hebbel, Robert P., et al.
Publicado: (2021)

(-)-Epigallocatechin-3-Gallate Inhibits eNOS Uncoupling and Alleviates High Glucose-Induced Dysfunction and Apoptosis of Human Umbilical Vein Endothelial Cells by PI3K/AKT/eNOS Pathway
por: Zhang, Zhiyong, et al.
Publicado: (2020)

(-)-Epigallocatechin-3-Gallate Inhibits eNOS Uncoupling and Alleviates High Glucose-Induced Dysfunction and Apoptosis of Human Umbilical Vein Endothelial Cells by PI3K/AKT/eNOS Pathway [Corrigendum]
Publicado: (2020)

Circulating microparticles are associated with plaque burden and cause eNOS uncoupling in patients with carotid atherosclerosis
por: Han, Xiaowan, et al.
Publicado: (2022)

Peroxynitrite Disrupts Endothelial Caveolae Leading to eNOS Uncoupling and Diminished Flow-Mediated Dilation in Coronary Arterioles of Diabetic Patients
por: Cassuto, James, et al.
Publicado: (2014)

Increased NOX2 expression in astrocytes leads to eNOS uncoupling through dihydrofolate reductase in endothelial cells after subarachnoid hemorrhage
por: Miao, Shu-Hao, et al.
Publicado: (2023)

Mild Mitochondrial Uncoupling and Calorie Restriction Increase Fasting eNOS, Akt and Mitochondrial Biogenesis
por: Cerqueira, Fernanda M., et al.
Publicado: (2011)

Role of the eNOS Uncoupling and the Nitric Oxide Metabolic Pathway in the Pathogenesis of Autoimmune Rheumatic Diseases
por: Łuczak, Anna, et al.
Publicado: (2020)

Eicosapentaenoic Acid Protects against Palmitic Acid-Induced Endothelial Dysfunction via Activation of the AMPK/eNOS Pathway
por: Lee, Che-Hsin, et al.
Publicado: (2014)

PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G(+) -Toxins
por: Chen, Feng, et al.
Publicado: (2014)

Neurogranin regulates eNOS function and endothelial activation
por: Cheriyan, Vino T., et al.
Publicado: (2020)

Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS
por: Morsy, Mohamed A., et al.
Publicado: (2014)

The microRNA-7-mediated reduction in EPAC-1 contributes to vascular endothelial permeability and eNOS uncoupling in murine experimental retinopathy
por: Garcia-Morales, Veronica, et al.
Publicado: (2017)

Naringenin upregulates GTPCH1/eNOS to ameliorate high glucose-induced retinal endothelial cell injury
por: Xue, Bing, et al.
Publicado: (2022)

Endothelial NO Production Is Mandatory for Epigallocatechin-3-Gallate–induced Vasodilation: Results From eNOS Knockout (eNOS(−/−)) Mice
por: Lorenz, Mario, et al.
Publicado: (2015)

Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet‐induced obesity
por: Ali, M. Irfan, et al.
Publicado: (2015)

Total flavonoids from Astragalus alleviate endothelial dysfunction by activating the Akt/eNOS pathway
por: Liu, Qian, et al.
Publicado: (2017)

Metformin Prevents Endothelial Dysfunction in Endometriosis through Downregulation of ET-1 and Upregulation of eNOS
por: Martins, Ana Filipa, et al.
Publicado: (2022)

Berberine Protects against Palmitate-Induced Endothelial Dysfunction: Involvements of Upregulation of AMPK and eNOS and Downregulation of NOX4
por: Zhang, Ming, et al.
Publicado: (2013)

Rhynchophylline Ameliorates Endothelial Dysfunction via Src-PI3K/Akt-eNOS Cascade in the Cultured Intrarenal Arteries of Spontaneous Hypertensive Rats
por: Hao, Hui-Feng, et al.
Publicado: (2017)

Pretreatment with β-Boswellic Acid Improves Blood Stasis Induced Endothelial Dysfunction: Role of eNOS Activation
por: Wang, Mingming, et al.
Publicado: (2015)

p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity
por: Yu, Yi, et al.
Publicado: (2014)

Molecular mechanisms underlying pharmacological stimulation of eNOS expression and eNOS activity
por: Li, Huige, et al.
Publicado: (2009)

Endothelial cell-specific loss of eNOS differentially affects endothelial function
por: Bu, Shuhan, et al.
Publicado: (2022)

Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats
por: Wang, Qiuyue, et al.
Publicado: (2022)

New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease
por: Daiber, Andreas, et al.
Publicado: (2019)

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells
por: Chen, Zhenlong, et al.
Publicado: (2018)

Sex-specific eNOS activity and function in human endothelial cells
por: Cattaneo, Maria Grazia, et al.
Publicado: (2017)

“Non alcoholic fatty liver disease and eNOS dysfunction in humans”
por: Persico, Marcello, et al.
Publicado: (2017)

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway
por: He, Huan, et al.
Publicado: (2020)

Genetic Scores of eNOS, ACE and VEGFA Genes Are Predictive of Endothelial Dysfunction Associated Osteoporosis in Postmenopausal Women
por: Singh, Puneetpal, et al.
Publicado: (2021)

Calcitriol Supplementation Ameliorates Microvascular Endothelial Dysfunction in Vitamin D-Deficient Diabetic Rats by Upregulating the Vascular eNOS Protein Expression and Reducing Oxidative Stress
por: Wee, Chee Lee, et al.
Publicado: (2021)

Gastrodin prevents homocysteine‐induced human umbilical vein endothelial cells injury via PI3K/Akt/eNOS and Nrf2/ARE pathway
por: Chen, Jiyu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_svmsh9atv26o1rv3c7d2eul8ee