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Regenerative medicine in the retina: from stem cells to cell replacement therapy

Following the fast pace of the growing field of stem cell research, retinal cell replacement is finally emerging as a feasible mean to be explored for clinical application. Although neuroprotective treatments are able to slow the progression of retinal degeneration caused by diseases such as age-rel...

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Detalles Bibliográficos
Autores principales: Oswald, Julia, Baranov, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016968/
https://www.ncbi.nlm.nih.gov/pubmed/29998222
http://dx.doi.org/10.1177/2515841418774433
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author Oswald, Julia
Baranov, Petr
author_facet Oswald, Julia
Baranov, Petr
author_sort Oswald, Julia
collection PubMed
description Following the fast pace of the growing field of stem cell research, retinal cell replacement is finally emerging as a feasible mean to be explored for clinical application. Although neuroprotective treatments are able to slow the progression of retinal degeneration caused by diseases such as age-related macular degeneration and glaucoma, they are insufficient to fully halt disease progression and unable to recover previously lost vision. Comprehensive, technological and intellectual advances over the past years, including the in vitro differentiation of retinal cells at manufacturing scale from embryonic stem (ES) cell and induced pluripotent stem (iPS) cell cultures, progress within the area of retinal disease modeling, and the first clinical trials have started to shape the way towards addressing this treatment gap and translating retinal cell replacement to the clinic. Here, summarize the most recent advances within retinal cell replacement from both a scientific and clinical perspective, and discuss the remaining challenges towards the delivery of the first retinal cell products.
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spelling pubmed-60169682018-07-11 Regenerative medicine in the retina: from stem cells to cell replacement therapy Oswald, Julia Baranov, Petr Ther Adv Ophthalmol Review Following the fast pace of the growing field of stem cell research, retinal cell replacement is finally emerging as a feasible mean to be explored for clinical application. Although neuroprotective treatments are able to slow the progression of retinal degeneration caused by diseases such as age-related macular degeneration and glaucoma, they are insufficient to fully halt disease progression and unable to recover previously lost vision. Comprehensive, technological and intellectual advances over the past years, including the in vitro differentiation of retinal cells at manufacturing scale from embryonic stem (ES) cell and induced pluripotent stem (iPS) cell cultures, progress within the area of retinal disease modeling, and the first clinical trials have started to shape the way towards addressing this treatment gap and translating retinal cell replacement to the clinic. Here, summarize the most recent advances within retinal cell replacement from both a scientific and clinical perspective, and discuss the remaining challenges towards the delivery of the first retinal cell products. SAGE Publications 2018-04-26 /pmc/articles/PMC6016968/ /pubmed/29998222 http://dx.doi.org/10.1177/2515841418774433 Text en © The Author(s), 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Oswald, Julia
Baranov, Petr
Regenerative medicine in the retina: from stem cells to cell replacement therapy
title Regenerative medicine in the retina: from stem cells to cell replacement therapy
title_full Regenerative medicine in the retina: from stem cells to cell replacement therapy
title_fullStr Regenerative medicine in the retina: from stem cells to cell replacement therapy
title_full_unstemmed Regenerative medicine in the retina: from stem cells to cell replacement therapy
title_short Regenerative medicine in the retina: from stem cells to cell replacement therapy
title_sort regenerative medicine in the retina: from stem cells to cell replacement therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016968/
https://www.ncbi.nlm.nih.gov/pubmed/29998222
http://dx.doi.org/10.1177/2515841418774433
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