Cargando…
Regenerative medicine in the retina: from stem cells to cell replacement therapy
Following the fast pace of the growing field of stem cell research, retinal cell replacement is finally emerging as a feasible mean to be explored for clinical application. Although neuroprotective treatments are able to slow the progression of retinal degeneration caused by diseases such as age-rel...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016968/ https://www.ncbi.nlm.nih.gov/pubmed/29998222 http://dx.doi.org/10.1177/2515841418774433 |
_version_ | 1783334643615924224 |
---|---|
author | Oswald, Julia Baranov, Petr |
author_facet | Oswald, Julia Baranov, Petr |
author_sort | Oswald, Julia |
collection | PubMed |
description | Following the fast pace of the growing field of stem cell research, retinal cell replacement is finally emerging as a feasible mean to be explored for clinical application. Although neuroprotective treatments are able to slow the progression of retinal degeneration caused by diseases such as age-related macular degeneration and glaucoma, they are insufficient to fully halt disease progression and unable to recover previously lost vision. Comprehensive, technological and intellectual advances over the past years, including the in vitro differentiation of retinal cells at manufacturing scale from embryonic stem (ES) cell and induced pluripotent stem (iPS) cell cultures, progress within the area of retinal disease modeling, and the first clinical trials have started to shape the way towards addressing this treatment gap and translating retinal cell replacement to the clinic. Here, summarize the most recent advances within retinal cell replacement from both a scientific and clinical perspective, and discuss the remaining challenges towards the delivery of the first retinal cell products. |
format | Online Article Text |
id | pubmed-6016968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-60169682018-07-11 Regenerative medicine in the retina: from stem cells to cell replacement therapy Oswald, Julia Baranov, Petr Ther Adv Ophthalmol Review Following the fast pace of the growing field of stem cell research, retinal cell replacement is finally emerging as a feasible mean to be explored for clinical application. Although neuroprotective treatments are able to slow the progression of retinal degeneration caused by diseases such as age-related macular degeneration and glaucoma, they are insufficient to fully halt disease progression and unable to recover previously lost vision. Comprehensive, technological and intellectual advances over the past years, including the in vitro differentiation of retinal cells at manufacturing scale from embryonic stem (ES) cell and induced pluripotent stem (iPS) cell cultures, progress within the area of retinal disease modeling, and the first clinical trials have started to shape the way towards addressing this treatment gap and translating retinal cell replacement to the clinic. Here, summarize the most recent advances within retinal cell replacement from both a scientific and clinical perspective, and discuss the remaining challenges towards the delivery of the first retinal cell products. SAGE Publications 2018-04-26 /pmc/articles/PMC6016968/ /pubmed/29998222 http://dx.doi.org/10.1177/2515841418774433 Text en © The Author(s), 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Oswald, Julia Baranov, Petr Regenerative medicine in the retina: from stem cells to cell replacement therapy |
title | Regenerative medicine in the retina: from stem cells to cell replacement therapy |
title_full | Regenerative medicine in the retina: from stem cells to cell replacement therapy |
title_fullStr | Regenerative medicine in the retina: from stem cells to cell replacement therapy |
title_full_unstemmed | Regenerative medicine in the retina: from stem cells to cell replacement therapy |
title_short | Regenerative medicine in the retina: from stem cells to cell replacement therapy |
title_sort | regenerative medicine in the retina: from stem cells to cell replacement therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016968/ https://www.ncbi.nlm.nih.gov/pubmed/29998222 http://dx.doi.org/10.1177/2515841418774433 |
work_keys_str_mv | AT oswaldjulia regenerativemedicineintheretinafromstemcellstocellreplacementtherapy AT baranovpetr regenerativemedicineintheretinafromstemcellstocellreplacementtherapy |