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Impact & Blast Traumatic Brain Injury: Implications for Therapy

Traumatic brain injury (TBI) is one of the most frequent causes of combat casualties in Operations Iraqi Freedom (OIF), Enduring Freedom (OEF), and New Dawn (OND). Although less common than combat-related blast exposure, there have been significant numbers of blast injuries in civilian populations i...

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Detalles Bibliográficos
Autores principales: Yamamoto, Satoshi, DeWitt, Douglas S., Prough, Donald S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017013/
https://www.ncbi.nlm.nih.gov/pubmed/29373501
http://dx.doi.org/10.3390/molecules23020245
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author Yamamoto, Satoshi
DeWitt, Douglas S.
Prough, Donald S.
author_facet Yamamoto, Satoshi
DeWitt, Douglas S.
Prough, Donald S.
author_sort Yamamoto, Satoshi
collection PubMed
description Traumatic brain injury (TBI) is one of the most frequent causes of combat casualties in Operations Iraqi Freedom (OIF), Enduring Freedom (OEF), and New Dawn (OND). Although less common than combat-related blast exposure, there have been significant numbers of blast injuries in civilian populations in the United States. Current United States Department of Defense (DoD) ICD-9 derived diagnoses of TBI in the DoD Health Care System show that, for 2016, severe and moderate TBIs accounted for just 0.7% and 12.9%, respectively, of the total of 13,634 brain injuries, while mild TBIs (mTBIs) accounted for 86% of the total. Although there is a report that there are differences in the frequency of long-term complications in mTBI between blast and non-blast TBIs, clinical presentation is classified by severity score rather than mechanism because severity scoring is associated with prognosis in clinical practice. Blast TBI (bTBI) is unique in its pathology and mechanism, but there is no treatment specific for bTBIs—these patients are treated similarly to TBIs in general and therapy is tailored on an individual basis. Currently there is no neuroprotective drug recommended by the clinical guidelines based on evidence.
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spelling pubmed-60170132018-11-13 Impact & Blast Traumatic Brain Injury: Implications for Therapy Yamamoto, Satoshi DeWitt, Douglas S. Prough, Donald S. Molecules Review Traumatic brain injury (TBI) is one of the most frequent causes of combat casualties in Operations Iraqi Freedom (OIF), Enduring Freedom (OEF), and New Dawn (OND). Although less common than combat-related blast exposure, there have been significant numbers of blast injuries in civilian populations in the United States. Current United States Department of Defense (DoD) ICD-9 derived diagnoses of TBI in the DoD Health Care System show that, for 2016, severe and moderate TBIs accounted for just 0.7% and 12.9%, respectively, of the total of 13,634 brain injuries, while mild TBIs (mTBIs) accounted for 86% of the total. Although there is a report that there are differences in the frequency of long-term complications in mTBI between blast and non-blast TBIs, clinical presentation is classified by severity score rather than mechanism because severity scoring is associated with prognosis in clinical practice. Blast TBI (bTBI) is unique in its pathology and mechanism, but there is no treatment specific for bTBIs—these patients are treated similarly to TBIs in general and therapy is tailored on an individual basis. Currently there is no neuroprotective drug recommended by the clinical guidelines based on evidence. MDPI 2018-01-26 /pmc/articles/PMC6017013/ /pubmed/29373501 http://dx.doi.org/10.3390/molecules23020245 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yamamoto, Satoshi
DeWitt, Douglas S.
Prough, Donald S.
Impact & Blast Traumatic Brain Injury: Implications for Therapy
title Impact & Blast Traumatic Brain Injury: Implications for Therapy
title_full Impact & Blast Traumatic Brain Injury: Implications for Therapy
title_fullStr Impact & Blast Traumatic Brain Injury: Implications for Therapy
title_full_unstemmed Impact & Blast Traumatic Brain Injury: Implications for Therapy
title_short Impact & Blast Traumatic Brain Injury: Implications for Therapy
title_sort impact & blast traumatic brain injury: implications for therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017013/
https://www.ncbi.nlm.nih.gov/pubmed/29373501
http://dx.doi.org/10.3390/molecules23020245
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