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Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of A Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor

In order to systematically explore and better understand the structure-activity relationship (SAR) of a diarylmethane backbone in the design of potent uric acid transporter 1 (URAT1) inhibitors, 33 compounds (1a–1x and 1ha–1hi) were designed and synthesized, and their in vitro URAT1 inhibitory activ...

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Detalles Bibliográficos
Autores principales:	Cai, Wenqing, Wu, Jingwei, Liu, Wei, Xie, Yafei, Liu, Yuqiang, Zhang, Shuo, Xu, Weiren, Tang, Lida, Wang, Jianwu, Zhao, Guilong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017028/ https://www.ncbi.nlm.nih.gov/pubmed/29382075 http://dx.doi.org/10.3390/molecules23020252

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