Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray

Hyperjaponol H (1), a new filicinic acid-based meroterpenoid, with a 6/6/10 ring system trans-fused by hetero-Diels–Alder cycloaddition between a germacrane sesquiterpenoid and a filicinic acid moiety, was isolated from aerial parts of Hypericum japonicum. The elucidation of its structure and absolu...

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Autores principales: Wu, Rongrong, Le, Zijun, Wang, Zhenzhen, Tian, Shuying, Xue, Yongbo, Chen, Yong, Hu, Linzhen, Zhang, Yonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017031/
https://www.ncbi.nlm.nih.gov/pubmed/29562631
http://dx.doi.org/10.3390/molecules23030683
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author Wu, Rongrong
Le, Zijun
Wang, Zhenzhen
Tian, Shuying
Xue, Yongbo
Chen, Yong
Hu, Linzhen
Zhang, Yonghui
author_facet Wu, Rongrong
Le, Zijun
Wang, Zhenzhen
Tian, Shuying
Xue, Yongbo
Chen, Yong
Hu, Linzhen
Zhang, Yonghui
author_sort Wu, Rongrong
collection PubMed
description Hyperjaponol H (1), a new filicinic acid-based meroterpenoid, with a 6/6/10 ring system trans-fused by hetero-Diels–Alder cycloaddition between a germacrane sesquiterpenoid and a filicinic acid moiety, was isolated from aerial parts of Hypericum japonicum. The elucidation of its structure and absolute configuration were accomplished by the analyses of extensive spectroscopic data and the comparison of Cotton effects of electron circular dichroism (ECD) with previously reported ones. The bioactivity assay showed that hyperjaponol H exhibited a moderate inhibitory efficacy on lytic Epstein-Barr virus (EBV) DNA replication in B95-8 cells.
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spelling pubmed-60170312018-11-13 Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray Wu, Rongrong Le, Zijun Wang, Zhenzhen Tian, Shuying Xue, Yongbo Chen, Yong Hu, Linzhen Zhang, Yonghui Molecules Article Hyperjaponol H (1), a new filicinic acid-based meroterpenoid, with a 6/6/10 ring system trans-fused by hetero-Diels–Alder cycloaddition between a germacrane sesquiterpenoid and a filicinic acid moiety, was isolated from aerial parts of Hypericum japonicum. The elucidation of its structure and absolute configuration were accomplished by the analyses of extensive spectroscopic data and the comparison of Cotton effects of electron circular dichroism (ECD) with previously reported ones. The bioactivity assay showed that hyperjaponol H exhibited a moderate inhibitory efficacy on lytic Epstein-Barr virus (EBV) DNA replication in B95-8 cells. MDPI 2018-03-18 /pmc/articles/PMC6017031/ /pubmed/29562631 http://dx.doi.org/10.3390/molecules23030683 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Rongrong
Le, Zijun
Wang, Zhenzhen
Tian, Shuying
Xue, Yongbo
Chen, Yong
Hu, Linzhen
Zhang, Yonghui
Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray
title Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray
title_full Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray
title_fullStr Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray
title_full_unstemmed Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray
title_short Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray
title_sort hyperjaponol h, a new bioactive filicinic acid-based meroterpenoid from hypericum japonicum thunb. ex murray
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017031/
https://www.ncbi.nlm.nih.gov/pubmed/29562631
http://dx.doi.org/10.3390/molecules23030683
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